HPV Human Papillomavirus Leads to Dysregulation of Immune Responses Through Epigenetic Mechanisms
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

HPV Human Papillomavirus Leads to Dysregulation of Immune Responses Through Epigenetic Mechanisms

Human papillomaviruses (HPV) are a diverse group of small double-stranded DNA viruses with specific mucosal or cutaneous tropisms. It is estimated that up to 80% of sexually active individuals will become infected with HPV sometime in their lifetime, making HPV the most prevalent sexually transmitted infection. HPVs can be further …

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Sex Differences in the zebrafish brain.
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Plenty of Fish in the Sea but Only Two Kinds of Brains: Epigenetic Sex differences in Zebrafish Brain

Phenotypic differences between males and females of a species are referred to as sexual dimorphism. Sexual dimorphism manifests not only in morphological traits, but also in physiological and behavioural traits. In organisms that do not have sex chromosomes, males and females are both derived from a nearly identical genome. Such …

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Gene Imprinting
DNA Methylation and HydroxymethylationImprinting and Inheritance

Genomic imprinting – new insight into the methylation patterns of humans

Genomic imprinting is an epigenetic gene-marking phenomenon that is mostly established in germline and results in monoallelic gene expression according to parental origin.1 The process of genomic imprinting is associated with prenatal development providing functions necessary for normal fetal growth. In addition to prenatal expression, postnatal gene imprinting may also …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Diet and Cancer: phytochemicals as epigenetic modifiers

Diet and lifestyle can contribute to cancer development by inducing both epigenetic and genetic changes. These changes, in combination with an individuals’ original genetic make-up, can result in the disruption of key cellular processes leading to abnormal growth.1 Phytochemicals are chemical compounds that occur naturally in plants. Dietary phytochemicals have …

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DNA methylation as age prediction marker
DNA Methylation and HydroxymethylationTools & Technology

Whodunit? Using DNA Methylation in Forensics

For some reason crime scene investigations and murder mysteries seem to fascinate us. So much so, that the countless books and television shows never seem to get old. Like most things on television however, life in a forensics lab is often portrayed to be much more fantastical than real life …

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epigenetic processes underlying AD in 5XFAD mouse
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Epigenetic mechanisms are a driving force in familial Alzheimer’s disease

With the increasing of life expectancy, aging and age-related cognitive impairments are becoming one of the most important issues for human health. Alzheimer’s disease (AD) is the most common neurodegenerative disease and the major cause of dementia in the elderly. Along with cognitive impairment and memory loss, Alzheimer’s is also …

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Imaging technique reveals a unique epigenetic state in mammalian genome
DNA Methylation and HydroxymethylationTools & Technology

Imaging technique reveals a unique epigenetic state in mammalian genome

Epigenetic modifications are chemical processes that affect gene activity without altering the DNA sequencing. The two major DNA epigenetic modifications in the mammalian genome are 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), which are often referred to as the “fifth base” and “sixth base,” respectively. 5mC is generated by DNA methyltransferase (DNMTs) …

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DNA Methylation and HydroxymethylationTools & Technology

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

Numerous small- and large-scale studies have established a negative correlation between gene expression and methylation status of cytosine residues within gene regulatory elements, such as promoters and enhancers. However, the functional follow-up studies of the established relationship have been limited due to the lack of methods for precise manipulation of …

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