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Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Epigenetic Regulation is Involved in Host Antiviral Defense Mechanisms

Influenza is the virus that causes the flu, and can result in serious, sometimes fatal infections.  Influenza virus is easily transmitted within a population raising concerns of it causing an epidemic, or worse, a pandemic.  In recent years, the highly pathogenic H5N1 and H1N1 viruses have caused thousands of deaths …

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DNA methylation & histone modification
DNA Methylation and HydroxymethylationHistone ModificationsTools & Technology

Analyzing two epigenetic marks (DNA methylation and histone modification) by one sequencing run

Epigenetic regulation is a complicated network involving DNA methylation, histone modification and non-coding RNAs, which all play in concert to control the epigenetic machinery. The cross talk between DNA methylation and histone modification is one of the most important interactions in establishing the epigenetic signature and was traditionally studied using …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Does Epigenetics Control Aging? New study finds DNA methylation patterns change with age

Aging is a natural part of life, but many of the molecular details that contribute to the aging process remain unclear and cannot be explained by classical genetics.  There are several age-related DNA methylation biomarkers, suggesting that epigenetics is involved in aging, but until recently there has not been a …

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5mc to 5hmc
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Potential of 5-hmC and TET Expression as Cancer Biomarkers

The role of epigenetics in cancer and developmental biology has become the focus of extensive research. 5-hydoxymethylcytosine (5-hmC) is an epigenetic modification that arises from the oxidation of 5-methylcytosine (5-mC) by the epigenetic regulatory proteins belonging to the TET (ten-eleven translocation) family of α-ketoglutarate-dependent deoxygenases.  The TET enzymes are responsible …

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