Seafood toxins alter DNA methylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Sex-specific Alterations in DNA Methylation from Prenatal Exposure to Seafood Toxins

Exposure to toxins in the womb can alter DNA methylation in the offspring [1], [2], persisting after birth [3]. Changes in DNA methylation in umbilical cord white blood cells (UCWBCs) have been linked to increased prevalence of disease, such as asthma [4]. To date, studies have dealt with a single …

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Inflammation and Cognitive Decline
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Age-related Dysregulation of Cytokine CXCL10 is Linked to Cognitive Decline

Chronic inflammation is a hallmark of aging pathology [1], [2]. Chronic inflammation is a risk factor for decreased cognitive performance [3], [4] and dementia [5] in older populations. Bradborn et al analyzed 35 cytokines in humans from the MyoAge study [6] to determine which are important for cognitive decline and …

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Sperm transfer aged epigenome to offspring
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance

Advanced Paternal Age at Conception Increases Risk of Age-Related Diseases in Offspring

As a person ages, they become more prone to diseases, including cancer and neurodegeneration. Having children when you are older can also affect the health of your offspring, increasing the risk for neuropsychiatric disorders, among many others [1], [2]. Sperm contribute epigenetic information to the zygote [3] that can affect …

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DNA Methylation & Lifespan
Aging, Environment, & DiseaseArticle SummariesDNA Methylation and Hydroxymethylation

DNA Methylation Rate May Determine Lifespan in Mammals

Species within the class Mammalia have a wide range of lifespans, from mice with a lifespan of 2 years to humans with a lifespan of over 100 years. Several non-molecular theories have been proposed to explain these lifespan variations, including body mass and metabolic rate [1]. Alternatively, research on ageing-associated …

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Sex Influences Brain Aging by Impacting DNA Methylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Sex Influences Brain Aging by Impacting DNA Methylation

While sex differences across aging and in the incidence of neurodegenerative diseases are well documented, relatively little data is available that compares sex-specific epigentic changes in the aging brain.1  Recent studies have identified specific loci with age-realted hyper- or hypo- methylation changes in liver, lung, and heart – but no …

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DNA methylation is as active mark of aging and age-related cognitive impairment in the medial prefrontal cortex
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

DNA Methylation is as Active Mark of Aging and Cognitive Impairment

Aging and age-related cognitive decline have been reported to be associated to transcriptomic alterations related to neural activity, synaptic plasticity and inflammation in specific brain regions, including the hippocampus and the medial prefrontal cortex (mPFC).1-4  Furthermore, previous epigenetic studies indicate that DNA methylation in the hippocampus is linked to cognitive …

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Mitochondrial epigenetics neurodegeneration
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

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Epigenetics and Obesity
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Epigenetic Marks Associated to Severe Obesity

There is growing evidence that DNA methylation might contribute to obesity. Candidate gene methylation studies in animal models and humans have demonstrated methylation changes in promoters of various genes that are implicated in obesity, appetite control and/or metabolism, insulin signaling, immunity, growth and circadian clock regulation. Severe obesity in children …

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