Frog Eyes Might Be Key to Retinal Regeneration
Chromatin StructureDevelopmental Biology & Stem CellsDNA Methylation and HydroxymethylationHistone Modifications

Frog Eyes Might Be the Key to Retinal Regeneration

Often said to be the windows to the soul, our eyes are one of the main ways we perceive the world around us. Vision loss, whether due to aging or injury, can be devastating and often hinders the ability to work, leading to economic stress [1]. Current treatments for vision …

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Beneficial Effect of Exercise on DNA Methylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

The Beneficial Effect of Exercise on DNA Methylation

As difficult as it may be to drag ourselves out of bed in the morning to go for a run or fit in a quick trip to the gym after work, regular exercise is essential for a healthy life. Research has shown that regular physical exercise reduces the risk of …

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How Jet Lag Impacts Epigenetics
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Up All Night and Asleep All Day: How Jet Lag Impacts Epigenetics

Anyone who has ever dragged themselves off of a red-eye flight, understands the exhaustion of jet lag. Depending on how far you’ve traveled, the effects of jet lag can last from days to weeks, leading to sleepless nights and tired days as your body attempts to reset its circadian clock. …

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Ripening Oranges with Epigenetics
DNA Methylation and Hydroxymethylation

Ripening Oranges with Epigenetics

Have you ever tried to peel an orange that wasn’t quite ripe yet? The peel sticks to the fruit, coming off in frustratingly small segments. Over the years, scientists have found that many different factors regulate the process of fruit ripening. The most well-known of these are plant hormones like …

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Implicating Methylation Variability in Depression
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Implicating Methylation Variability in Depression

When Scott Kelly touched back down to Earth after nearly a year in space, scientists found that he was no longer strictly identical to his twin brother Mark [1]. While Scott’s DNA sequence was no different from his brother’s, he did have a number of epigenetic changes compared to Mark. …

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Seafood toxins alter DNA methylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Sex-specific Alterations in DNA Methylation from Prenatal Exposure to Seafood Toxins

Exposure to toxins in the womb can alter DNA methylation in the offspring [1], [2], persisting after birth [3]. Changes in DNA methylation in umbilical cord white blood cells (UCWBCs) have been linked to increased prevalence of disease, such as asthma [4]. To date, studies have dealt with a single …

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Inflammation and Cognitive Decline
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Age-related Dysregulation of Cytokine CXCL10 is Linked to Cognitive Decline

Chronic inflammation is a hallmark of aging pathology [1], [2]. Chronic inflammation is a risk factor for decreased cognitive performance [3], [4] and dementia [5] in older populations. Bradborn et al analyzed 35 cytokines in humans from the MyoAge study [6] to determine which are important for cognitive decline and …

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Sperm transfer aged epigenome to offspring
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance

Advanced Paternal Age at Conception Increases Risk of Age-Related Diseases in Offspring

As a person ages, they become more prone to diseases, including cancer and neurodegeneration. Having children when you are older can also affect the health of your offspring, increasing the risk for neuropsychiatric disorders, among many others [1], [2]. Sperm contribute epigenetic information to the zygote [3] that can affect …

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