Losing Heterochromatin to Determine Cell Fate
Chromatin StructureDevelopmental Biology & Stem Cells

Losing Heterochromatin to Determine Cell Fate

In the moments after fertilization, the tiny mass that is the embryo sets in motion developmental programs that will transform it into a human being. One of the earliest steps in human development is the formation of the germ layers. Humans and other animals in the Chordata phylum, have three …

READ MORE →
shutterstock_139005989-300x294
DNA Methylation and HydroxymethylationTools & Technology

An epigenetic platform to study global DNA methylome and transcriptome in parallel from limited tissue such as early embryo

Recent technological advances and the exponential growth of the field of epigenetics, in particular genome-wide studies, are advancing our knowledge and providing more evidence for the interdependence of epigenetic and genetic variations. The importance of genome-wide epigenetic reprogramming in mammalian germ cells and early embryos has shed light on the …

READ MORE →