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Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Epigenetic reprogramming key to normal development

Somatic cell nuclear transfer (SCNT) defines the process in which a somatic cell’s nucleus is removed and then introduced into an enucleated oocyte, or egg cell. Following transfer, the nucleus is reprogrammed by factors in the oocyte such that it now possesses the ability to mitotically divide and form totipotent …

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Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Lost in translation? New findings suggest a critical role for cytosine methylation in tRNAs

While cytosine methylation in the DNA context will continue to be an important marker for epigenetic discoveries, current trends in the cytosine methylation game indicate diverse and critical roles of the modification in the RNA context. Much attention has been paid recently to findings in mRNA methylation, suggesting an important …

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5mC and 5hmC
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Maternal instincts: Protection of 5mC?

DNA modification by 5-methylcytosine (5mC) was the only recognized DNA modification for many years in mammals and 5mC plays important roles in cell differentiation and development. Recently, a novel 5-hydroxymethylcytosine (5hmC) DNA modification has been reported and the balance between 5mC and 5hmC in the genome is a critical step …

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