DNA Methylation and HydroxymethylationTools & Technology

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

Numerous small- and large-scale studies have established a negative correlation between gene expression and methylation status of cytosine residues within gene regulatory elements, such as promoters and enhancers. However, the functional follow-up studies of the established relationship have been limited due to the lack of methods for precise manipulation of …