A Flash-Frozen View of Condensing Chromatin
Chromatin Structure

A Flash-Frozen View of Condensing Chromatin

For cells to divide, they must first condense their DNA into the X-shape familiar from introductory biology textbooks. While the process of cell division has been studied for over 100 years, how exactly our DNA condenses in three-dimensions within the nucleus remains a mystery. To better understand this condensation process, …

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Chromatin StructureDevelopmental Biology & Stem Cells

3D Chromatin Organization, Transcription, and Behavior

The chromosomes of differentiated cells contain heterochromatic and euchromatic compartments. Heterochromatin is highly condensed and associated with repressed transcription, whereas in euchromatin  transcription is generally active. Spatial organization of heterochromatin can vary vastly among different differentiated cell types1. In contrast to differentiated cells, embryonic stem cells contain only sparse heterochromatic …

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The Y chromosome has genome-wide influences over chromatin structure and gene regulation
Chromatin StructureDevelopmental Biology & Stem Cells

The Y chromosome has genome-wide influences over chromatin structure and gene regulation

In mammals, the Y chromosome is responsible for determining the male sex by initiating the development of male-specific gonad tissues. Hormones, produced and secreted by the sex organs, are vital for initiating and maintaining sexual dimorphisms. However, differences seen between the sexes are not solely derived from hormones. In fact, …

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