Mapping the Chromatin Landscape of Cancers
Aging, Environment, & DiseaseChromatin StructureTools & Technology

Mapping the Chromatin Landscape of Cancers

A betrayal of our own cells against us, cancer is a devastating disease that affects over 18 million people world-wide [1]. With more than 200 different types of cancer, most with diverse modes of action and variable outcomes among people, a deeper understanding of how different cancers function and progress …

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Hypomethylation in cancer and aging
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Different DNA Hypomethylation Patterns in Cancer and Aging

The risk of developing cancer increases with age [1]. The mechanisms that increase the prevalence of cancer with age are not fully understood. Several studies have found the presence of polycomb-target gene promoter hypermethylation in aging and cancer [2], [3]. Perez et al researched whether aging and cancer share changes …

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Colorectal cancer and obesity
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Risk for Colorectal Cancer is Increased by Obesity-related Gene Expression Changes

Colorectal cancer is an age-related disease traditionally seen in populations over the age of 50. In recent years, colorectal cancer has become more prevalent in younger individuals, and obesity is thought to be a major risk factor. However, the molecular mechanisms underlying this increased risk remains unclear. Since DNA methylation …

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Epigenetics and Obesity
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Epigenetic Marks Associated to Severe Obesity

There is growing evidence that DNA methylation might contribute to obesity. Candidate gene methylation studies in animal models and humans have demonstrated methylation changes in promoters of various genes that are implicated in obesity, appetite control and/or metabolism, insulin signaling, immunity, growth and circadian clock regulation. Severe obesity in children …

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When the writing is wrong: PRMT5 histone methylation promotes invasivity and metastasis in a range of human cancers
Aging, Environment, & DiseaseHistone Modifications

When the writing is wrong: PRMT5 histone arginine methylation promotes invasivity and metastasis in a range of human cancers

Cancer metastasis occurs when cancer cells leave a primary tumor and invade other tissues. Generally, this leads to a poor prognosis for patients. Underlying epigenetic mechanisms of tumor progression are poorly understood but are of great interest for developing new approaches of treatment in the clinic. Cancer etiology is highly …

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HPV Human Papillomavirus Leads to Dysregulation of Immune Responses Through Epigenetic Mechanisms
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

HPV Human Papillomavirus Leads to Dysregulation of Immune Responses Through Epigenetic Mechanisms

Human papillomaviruses (HPV) are a diverse group of small double-stranded DNA viruses with specific mucosal or cutaneous tropisms. It is estimated that up to 80% of sexually active individuals will become infected with HPV sometime in their lifetime, making HPV the most prevalent sexually transmitted infection. HPVs can be further …

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shutterstock_383651506
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Diet and Cancer: phytochemicals as epigenetic modifiers

Diet and lifestyle can contribute to cancer development by inducing both epigenetic and genetic changes. These changes, in combination with an individuals’ original genetic make-up, can result in the disruption of key cellular processes leading to abnormal growth.1 Phytochemicals are chemical compounds that occur naturally in plants. Dietary phytochemicals have …

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Basal Cell Carcinoma - cancer
Aging, Environment, & DiseaseTools & Technology

A New and Targetable Epigenetic Biomarker for the Most Common Cancer

Basal cell carcinoma (BCC) is the most common cancer in people of Caucasian descent. BCC affects 2-3.5 million Americans yearly, and in some countries such as Denmark, BCCs outnumber all other cancers combined. Most BCCs can be successfully treated with surgery, particularly using Mohs micrographic surgical techniques, but some BCC …

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