DNA Methylation and HydroxymethylationTools & Technology

Epigenetics for All! New Tools Available for Genome-Wide Epigenetic Analysis

Zymo Research Corporation, The Epigenetics Company, recently expanded their services for genetic, epigenetic, and expression analysis.  As one of the pioneers in the field and with over a decade of experience in epigenetics research, Zymo Research started offering unique services for genome-wide DNA methylation analysis two years ago.  Since then, …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

A new web-based tool for high-throughput DNA methylation pathway analysis of multiple cancer types

Global cytosine hypomethylation and promoter hypermethylation are characteristic in cancer, but how DNA methylation targets biological pathways and gene sets is unclear. It is hypothesized that during tumorigenesis certain pathways and gene sets are commonly dysregulated via DNA methylation across cancer types. A logistic regression-based gene set enrichment method called …

5mc to 5hmc
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Potential of 5-hmC and TET Expression as Cancer Biomarkers

The role of epigenetics in cancer and developmental biology has become the focus of extensive research. 5-hydoxymethylcytosine (5-hmC) is an epigenetic modification that arises from the oxidation of 5-methylcytosine (5-mC) by the epigenetic regulatory proteins belonging to the TET (ten-eleven translocation) family of α-ketoglutarate-dependent deoxygenases.  The TET enzymes are responsible …