MicroRNAs Take Down Brain Cancer
Aging, Environment, & DiseaseRegulatory RNA

MicroRNAs Team Up to Take Down Brain Cancer

MicroRNAs are small but powerful molecules in the cell. Containing only around 22 nucleotides, these small RNA molecules are responsible for binding to and silencing messenger RNA sequences before they can be translated into proteins, and thus are incredibly important regulators of gene expression. MicroRNAs (miRs) often regulate the expression …

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Tau on the Epigenome of Alzheimer’s Brains
Aging, Environment, & Disease

Untangling the Role of Tau on the Epigenome of Alzheimer’s Brains

Forgetting where you put your car keys or the address of your aunt’s house is pretty normal, but for people with Alzheimer’s disease, this kind of forgetfulness and memory loss is just the tip of the iceberg. As the neurons in the brains of these patients degenerate, their memory loss …

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Inflammation and Cognitive Decline
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Age-related Dysregulation of Cytokine CXCL10 is Linked to Cognitive Decline

Chronic inflammation is a hallmark of aging pathology [1], [2]. Chronic inflammation is a risk factor for decreased cognitive performance [3], [4] and dementia [5] in older populations. Bradborn et al analyzed 35 cytokines in humans from the MyoAge study [6] to determine which are important for cognitive decline and …

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Sex Influences Brain Aging by Impacting DNA Methylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Sex Influences Brain Aging by Impacting DNA Methylation

While sex differences across aging and in the incidence of neurodegenerative diseases are well documented, relatively little data is available that compares sex-specific epigentic changes in the aging brain.1  Recent studies have identified specific loci with age-realted hyper- or hypo- methylation changes in liver, lung, and heart – but no …

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DNA methylation and hydroxymethylation in the aging brain
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

DNA methylation and hydroxymethylation in the aging brain – Not less, but where

Changes in DNA methylation have long been an area of interest for neurobiology of aging researchers.  With the recent reports of ‘aging’ DNA methylation clocks1,2 and the discovery of roles for methylation3 and hydroxymethylation4 in memory formation5 there is a heightened interest in examining changes in DNA modifications with aging …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Does Loss of DNA Methylation and Hydroxymethylation in the Brain Lead to Loss of Memory?

5-methylcytosine (5-mC) and 5-hydroxymethycytosine (5-hmC) are two major epigenetic modifications of DNA.  Dynamic changes in 5-mC and 5-hmC levels are tightly regulated and impact neural cell development, differentiation, and other biological functions. Deregulation of 5-mC and 5-hmC has also been implicated in various human diseases. However, whether 5-mC and 5-hmC …

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