Basal Cell Carcinoma - cancer
Aging, Environment, & DiseaseTools & Technology

A New and Targetable Epigenetic Biomarker for the Most Common Cancer

Basal cell carcinoma (BCC) is the most common cancer in people of Caucasian descent. BCC affects 2-3.5 million Americans yearly, and in some countries such as Denmark, BCCs outnumber all other cancers combined. Most BCCs can be successfully treated with surgery, particularly using Mohs micrographic surgical techniques, but some BCC …

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Aging, Environment, & DiseaseTools & Technology

Can Epigenetics Help Cure Diabetes and Obesity?

Sunitha Meruvu1, John Bowman2, Mahua Choudhury1 1Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA 2 Department of Pharmacy Practice, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA Obesity poses a serious burden on society, …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Identification of 21 DNA Hypermethylated Hotspots Associated with Breast Cancer Metastasis

Breast cancer is one of the most common diseases in women and almost an eighth of the women population is suffering from breast cancer. Currently, there are several methods to diagnose and treat breast cancer, including genetic screening. In 2013, Angelina Jolie announced that she carried the BRCA1 mutation and …

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DNA Methylation and HydroxymethylationRegulatory RNATools & Technology

Chewing Over Salivary Diagnostics and the Epigenome

Michael Wren, Elizabeth Shirtcliff, Stacy Drury Over the last decade there has been substantial advances in salivary biomarker development and diagnostics. Unlike blood draws, saliva collection is noninvasive, inexpensive, and convenient for repeated sampling, making it especially useful for research in vulnerable populations, such as young children, the sick, and …

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Histone ModificationsTools & Technology

Histone Cleavage Can Interfere with the Measurement of Downstream Modifications

Histone modifications are increasingly being used as biomarkers in molecular epidemiology studies. However, a recent report from researchers at Columbia University describes a distinct histone H3 cleavage product, identified by Western blot, in human peripheral blood mononuclear cells (PBMCs), which interferes with the measurement of certain histone modifications (Howe and …

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Cigarette Smoking, Epigenetics, and DNA Methylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Cigarette Smoking and Epigenetics: DNA Methylation Differences Between Ethnic Groups

Cigarette smoking leads to some of the most preventable causes of death and illness in the world. The Centers for Disease Control (CDC) in the United States has reported that there are approximately 440,000 deaths due to smoking each year, and an additional 49,000 deaths due to secondhand smoke.  Roughly …

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Epigenetics and Allergies
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

New Year, New Hay Fever Season, and New Role for Epigenetics in Allergies

Itching of the eyes and nose, nasal congestion, sneezing, and runny nose are some symptoms of Allergic Rhinitis, better known as hay fever or seasonal allergies, which affects ~30% of people worldwide. In a recent PLOS Genetics publication, scientists from Sweden and the US investigated genome-wide DNA methylation and gene …

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DNA Methylation Age Clock
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Wanna Be Forever 21? It May Be Possible By Resetting Your DNA Methylation Age Clock

As an organism ages, cells and tissues differentiate and change. These changes can include accumulation of DNA mutations, alterations to telomeres, decay of cellular and tissue structures, and changes in gene expression. Both differentiation of tissues and age effects are at least partially caused by epigenetic modifications of the genome, …

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