DNA Methylation Age Clock
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Wanna Be Forever 21? It May Be Possible By Resetting Your DNA Methylation Age Clock

As an organism ages, cells and tissues differentiate and change. These changes can include accumulation of DNA mutations, alterations to telomeres, decay of cellular and tissue structures, and changes in gene expression. Both differentiation of tissues and age effects are at least partially caused by epigenetic modifications of the genome, …

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DNA methylation dynamics
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

The Same, Only Different: DNA Methylation Dynamics in the Human Genome

DNA methylation is one of the most common, and most studied, epigenetic modifications.  DNA methylation plays a central role in the development and differentiation of mammalian cells, and when DNA methylation is misregulated, it can lead to many different types of human diseases, including cancer and neurological disorders.  DNA methylation, …

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DNA Methylation and HydroxymethylationTools & Technology

Genome-Wide 5-mC & 5-hmC Sequencing Guide

It is now well established that the classic genetic code is not sufficient to explain many complex phenotypes and causes of human diseases. Epigenetic modifications to DNA, such as methylcytosine (5-mC) and hydroxymethylcytosine (5-hmC), must also be considered as they can have profound effects on gene expression and are important …

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miRNA_3
Developmental Biology & Stem CellsRegulatory RNA

Soaking up the Competition – Circular RNAs as Molecular Sponges for miRNAs

Numerous families of non-coding RNAs have been identified in mammalian cells, including lncRNA, miRNA, siRNA, and piRNA.  Another type of RNA called circular RNA (circRNA) has remained a mysterious class, as the exact function of these molecules has not been described. Usually, circRNAs result from spicing events and have been …

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DNA Methylation and HydroxymethylationTools & Technology

Epigenetics for All! New Tools Available for Genome-Wide Epigenetic Analysis

Zymo Research Corporation, The Epigenetics Company, recently expanded their services for genetic, epigenetic, and expression analysis.  As one of the pioneers in the field and with over a decade of experience in epigenetics research, Zymo Research started offering unique services for genome-wide DNA methylation analysis two years ago.  Since then, …

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Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

A new web-based tool for high-throughput DNA methylation pathway analysis of multiple cancer types

Global cytosine hypomethylation and promoter hypermethylation are characteristic in cancer, but how DNA methylation targets biological pathways and gene sets is unclear. It is hypothesized that during tumorigenesis certain pathways and gene sets are commonly dysregulated via DNA methylation across cancer types. A logistic regression-based gene set enrichment method called …

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DNA Methylation and HydroxymethylationTools & Technology

Everything Starts with Good Primers

As “The Epigenetics Company”, Zymo Research Corporation is dedicated to developing and providing the most comprehensive set of tools for epigenetics research available. With this in mind, we provide on our website the Bisulfite Primer Seeker design program for the quick and easy generation of primers necessary for the PCR …

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encode
Tools & Technology

Initial ENCODE Project Data Published!

The human genome project revealed the sequence of the roughly 3 billion DNA bases and approximately 25,000 genes found within our cells.  But exactly how that information is interpreted to, for example, be able to produce the nearly 300 distinct cell types found in the human body is still unknown. …

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