Tau on the Epigenome of Alzheimer’s Brains
Aging, Environment, & Disease

Untangling the Role of Tau on the Epigenome of Alzheimer’s Brains

Forgetting where you put your car keys or the address of your aunt’s house is pretty normal, but for people with Alzheimer’s disease, this kind of forgetfulness and memory loss is just the tip of the iceberg. As the neurons in the brains of these patients degenerate, their memory loss …

Acetylation in Alzheimer's disease
Aging, Environment, & DiseaseChromatin StructureHistone Modifications

Dysregulation of Histone Acetylation in Alzheimer’s Disease

In Alzheimer’s disease (AD) pathology, neuronal histone acetylation is reduced at memory-related genes [1]. Nativio et al specifically researched H4K16ac, a regulator of chromatin compaction, because it plays an important role in cellular aging and senescence [2]. By comparing the genome-wide profiles of H4K16ac in brain tissues from AD patients …

Mitochondrial epigenetics neurodegeneration
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

Alzheimer’s & the Brain Stem
Aging, Environment, & DiseaseTools & Technology

Epigenetic Dysregulation Within the Brainstem in Alzheimer’s Disease

The elusive nature of the early stages of Alzheimer’s disease (AD) impedes scientific breakthroughs in diagnostics or efficient therapeutics for this devastating disorder. To date, the long-prevailing theories of genetic contribution do not adequately explain the pathogenesis of the disease and, alternatively, epigenetic regulation has been proposed as a key …

epigenetic processes underlying AD in 5XFAD mouse

Epigenetic mechanisms are a driving force in familial Alzheimer’s disease

With the increasing of life expectancy, aging and age-related cognitive impairments are becoming one of the most important issues for human health. Alzheimer’s disease (AD) is the most common neurodegenerative disease and the major cause of dementia in the elderly. Along with cognitive impairment and memory loss, Alzheimer’s is also …

Aging, Environment, & DiseaseTools & Technology

Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Neurodegeneration Therapy

Epigenetics play an important role in the proliferation and differentiation of stem cells, such as bone marrow derived mesenchymal stem cells (BM-MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). These stem cells can be epigenetically modified by introducing various factors into their culture media or growth environment …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNA

Epigenetics, Aging, and Neurodegeneration

Roy Lardenoije, Daniël van den Hove, and Bart Rutten Epigenetics is a booming, but highly complex and rapidly evolving field. Apart from the well-studied regulatory mechanisms involving DNA and histone modifications, and non-coding RNAs, there are the more recent additions of RNA methylation and editing, and reports of epigenetic regulation …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Does Loss of DNA Methylation and Hydroxymethylation in the Brain Lead to Loss of Memory?

5-methylcytosine (5-mC) and 5-hydroxymethycytosine (5-hmC) are two major epigenetic modifications of DNA.  Dynamic changes in 5-mC and 5-hmC levels are tightly regulated and impact neural cell development, differentiation, and other biological functions. Deregulation of 5-mC and 5-hmC has also been implicated in various human diseases. However, whether 5-mC and 5-hmC …