Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

AID/APOBEC – Unlikely Contenders for Primary DNA Demethylation Pathway.

Over the past couple of years, extensive efforts have been made to elucidate the 5-methylcytosine demethylation pathway. Two distinctly different families of enzymes were implicated as the most likely candidates.  The TET (ten-eleven translocation) family of α-ketoglutarate-dependent deoxygenases consists of enzymes which iteratively oxidize 5-methylcytosine to 5-carboxylcytosine, and represents one …