Oxidative Stress and Epigenetics: a Novel Link Established Through Histone Adduction
Aging, Environment, & DiseaseHistone Modifications

Oxidative Stress and Epigenetics: a Novel Link Established Through Histone Adduction

Damage to cellular macromolecules caused by reactive oxygen species (ROS) produced during oxidative stress contributes to the pathogenesis of many disease states. One target of ROS is the 1,4-diene structure of polyunsaturated fatty acids (PUFAs), which is highly susceptible to peroxidation. An important outcome of lipid peroxidation is the generation …

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