DNA methylation in the placenta
Developmental Biology & Stem CellsDNA Methylation and HydroxymethylationUncategorized

DNA Methylation in the Placenta: accelerated aging in pregnancy complications

The placenta is a unique organ as it is an extra-embryonic tissue primarily regulated by the fetal genome and shared between mother and fetus. However, it is a transient organ that is only needed throughout pregnancy and gestation and then is discarded after delivery. The essential role of the placenta …

epigenetic processes underlying AD in 5XFAD mouse

Epigenetic mechanisms are a driving force in familial Alzheimer’s disease

With the increasing of life expectancy, aging and age-related cognitive impairments are becoming one of the most important issues for human health. Alzheimer’s disease (AD) is the most common neurodegenerative disease and the major cause of dementia in the elderly. Along with cognitive impairment and memory loss, Alzheimer’s is also …

Histone ModificationsUncategorized

EZH2: A New Biomarker and Epigenetic Target for Retinoblastoma

Retinoblastoma (RB) is the most common primary eye cancer in children, the third most common cancer in infants younger than 1 year and accounts for 12% of all infantile cancers per year. RB can be blinding and lethal, and is caused by mutations in the tumor suppressor gene RB1. However, current …

shutterstock_232134673 (1)
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsUncategorized

Early-life Exposure to Substance Abuse and the Risk for Type 2 Diabetes

Type 2 diabetes (T2D) is a chronic non-communicable disease that generally develops after the age of 40 and therefore believed to be associated with aging. There is, however,increasing experimental and epidemiological evidence that risk of T2D and obesity which is an important risk factor for T2D may be epigenetically programmed during critical windows …