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A new web-based tool for high-throughput DNA methylation pathway analysis of multiple cancer types

Global cytosine hypomethylation and promoter hypermethylation are characteristic in cancer, but how DNA methylation targets biological pathways and gene sets is unclear. It is hypothesized that during tumorigenesis certain pathways and gene sets are commonly dysregulated via DNA methylation across cancer types. A logistic regression-based gene set enrichment method called …

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scale

WHEN IT COMES TO CANCER DRUGS, SOMETIMES LESS IS MORE

The chemotherapeutic drug decitabine (DAC) and its analog azacitidine (AZA) are FDA approved to treat cancers of the blood, such as myelodysplastic syndromes and certain types of leukemias. In high concentrations, DAC and AZA cause acute DNA damage followed by cell death. Currently, both drugs are limited to treatment of …

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Everything Starts with Good Primers

As “The Epigenetics Company”, Zymo Research Corporation is dedicated to developing and providing the most comprehensive set of tools for epigenetics research available. With this in mind, we provide on our website the Bisulfite Primer Seeker design program for the quick and easy generation of primers necessary for the PCR …

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encode

Initial ENCODE Project Data Published!

The human genome project revealed the sequence of the roughly 3 billion DNA bases and approximately 25,000 genes found within our cells.  But exactly how that information is interpreted to, for example, be able to produce the nearly 300 distinct cell types found in the human body is still unknown. …

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Discovery of the first chemical inhibitor of histone demethylation

The study of post-translational modification of histone tails represents one of the largest areas of research in the field of epigenetics.  An improved understanding of how these modifications are added, recognized, and removed is essential to understand the mechanisms underlying epigenetic-based human diseases and to allow for the discovery of …

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DNA methylation & histone modification

Analyzing two epigenetic marks (DNA methylation and histone modification) by one sequencing run

Epigenetic regulation is a complicated network involving DNA methylation, histone modification and non-coding RNAs, which all play in concert to control the epigenetic machinery. The cross talk between DNA methylation and histone modification is one of the most important interactions in establishing the epigenetic signature and was traditionally studied using …

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Prediction of polyadenylation site usage from epigenetic modifications

In this computational study, the authors explore several links between epigenetic factors (including DNA methylation, nucleosomal association, and histone modifications) and the usage of polyadenylation (poly(A)) sites in transcribed messages.

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