Patient-derived tumor xenograft models (PDXs) for ovarian cancer

A Better Model System for Ovarian Cancer: Patient-derived tumor xenografts (PDXs) are suitable for epigenetic methylome-based cancer research

Ovarian cancer is the most lethal gynecologic malignancy. After epigenomic analysis of patient tumors, aberrant DNA methylation patterns are universally observed in the most abundant histological subtype of ovarian cancer, high-grade serous ovarian cancer (HGSOC). These epigenetic modifications like DNA methylation are known to frequently affect gene regulation involved in …

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DNA methylation as age prediction marker

Whodunit? Using DNA Methylation in Forensics

For some reason crime scene investigations and murder mysteries seem to fascinate us. So much so, that the countless books and television shows never seem to get old. Like most things on television however, life in a forensics lab is often portrayed to be much more fantastical than real life …

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Basal Cell Carcinoma - cancer

A New and Targetable Epigenetic Biomarker for the Most Common Cancer

Basal cell carcinoma (BCC) is the most common cancer in people of Caucasian descent. BCC affects 2-3.5 million Americans yearly, and in some countries such as Denmark, BCCs outnumber all other cancers combined. Most BCCs can be successfully treated with surgery, particularly using Mohs micrographic surgical techniques, but some BCC …

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Imaging technique reveals a unique epigenetic state in mammalian genome

Imaging technique reveals a unique epigenetic state in mammalian genome

Epigenetic modifications are chemical processes that affect gene activity without altering the DNA sequencing. The two major DNA epigenetic modifications in the mammalian genome are 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC), which are often referred to as the “fifth base” and “sixth base,” respectively. 5mC is generated by DNA methyltransferase (DNMTs) …

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Repurposing the CRISPR-Cas9 system for targeted DNA methylation

Numerous small- and large-scale studies have established a negative correlation between gene expression and methylation status of cytosine residues within gene regulatory elements, such as promoters and enhancers. However, the functional follow-up studies of the established relationship have been limited due to the lack of methods for precise manipulation of …

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(epi)Genes in Space!

Think back to when you were 17 years old. Most likely, your afternoons did not involve planning experiments that would be conducted aboard the International Space Station (ISS) while you were racing to track practice or chorus rehearsal after school. For Anna-Sophia Boguraev however, this is her reality. In July, …

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Neurodegeneration

Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Neurodegeneration Therapy

Epigenetics play an important role in the proliferation and differentiation of stem cells, such as bone marrow derived mesenchymal stem cells (BM-MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). These stem cells can be epigenetically modified by introducing various factors into their culture media or growth environment …

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Can Epigenetics Help Cure Diabetes and Obesity?

Sunitha Meruvu1, John Bowman2, Mahua Choudhury1 1Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA 2 Department of Pharmacy Practice, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX, USA Obesity poses a serious burden on society, …

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