Mapping the Chromatin Landscape of Cancers

Mapping the Chromatin Landscape of Cancers

A betrayal of our own cells against us, cancer is a devastating disease that affects over 18 million people world-wide [1]. With more than 200 different types of cancer, most with diverse modes of action and variable outcomes among people, a deeper understanding of how different cancers function and progress …

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Simultaneous Gene Expression and Chromatin Landscape in Single Cells

A Simultaneous Picture of Gene Expression and Chromatin Landscape in Single Cells

As we move through the day, it’s easy to forget that individual cells, organized into tissues and tissues into organs, act in harmony to give us life. Over the years, scientists have developed new techniques to investigate how gene expression, chromatin state, and methylation determines developmental behavior, at the level …

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Predicting Double-Strand Breaks

Accurately Predicting Double-Strand Breaks Using Public Genetic Databases

Double-strand breaks (DSBs) cause chromosomal rearrangements, such as deletions, translocations, and fusions of DNA [1]. This results in a host of issues with cellular function, making it important to map where DSBs can occur in the genome. Mourad et al used public data on the epigenome, chromatin structure, DNA motifs, …

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Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

          In Mathias Malzieu’s novel “The Boy with the Cuckoo-Clock Heart”, Jack is born with a frozen, dysfunctional heart which, fortunately for him, is soon replaced with a workable heart made from a cuckoo clock. If found in a similar situation, who would not desire such an amazing, albeit strange, miracle? …

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Epigenetic Diagnostics

Epigenetic Diagnostics: Locus-specific DNA Methylation Testing Poised for Clinical Impact

Precision medicine holds great potential to make a direct positive impact in the clinic. A growing number of diagnostic panels addressing a list of disease indications are now available for testing. Currently most tests are designed for genetic analysis of sample DNA to help inform treatment decisions. With a few …

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Alzheimer’s & the Brain Stem

Epigenetic Dysregulation Within the Brainstem in Alzheimer’s Disease

The elusive nature of the early stages of Alzheimer’s disease (AD) impedes scientific breakthroughs in diagnostics or efficient therapeutics for this devastating disorder. To date, the long-prevailing theories of genetic contribution do not adequately explain the pathogenesis of the disease and, alternatively, epigenetic regulation has been proposed as a key …

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epigenetic mechanisms in allergic diseases

Asthma & Histone Acetylation: an important epigenetic mechanism in allergic diseases

Epigenetic regulation is thought to be one of the most important mechanisms contributing to the development and clinical course of chronic immunological diseases like allergies and asthma. DNA methylation has been extensively studied in this context, which has not been a case of histone modifications such as histone acetylation or …

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ncRNA is Synergistically Regulated by Various Epi-Modifications

Non-coding RNA Expression is Synergistically modulated by Various Types of Epigenetic Modifications

It is well known that most of the mammalian genome is transcribed, producing large amounts of non-coding RNAs (ncRNAs). The two main types of ncRNA are micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs). MiRNAs are a recently discovered and well-characterized class of ncRNAs that are frequently dysregulated in different …

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