DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity.

De Novo DNA Cytosine Methyltransferase Enzyme Dynamics

The DNA methyltransferases (DNMT) are one busy enzyme family! While they are responsible for establishing and maintaining the mammalian cytosine methylome, they aren’t one and the same, as they take on some diverse roles. The DNMTs can from complexes with more than one DNMT to accomplish additional functions and their …

Figure 1: Factors involved in impaired male infertility due to reproductive aging.

Paternal Age and Epigenetics

Maternal aging has been shown to cause infertility, pregnancy complications, spontaneous abortion, congenital anomalies, and perinatal complications. However, the impact of paternal ageing on semen quality and reproductive function has still been controversial. To address this, Drs. Sharma, Professor Agarwal and their co-authors have extensively reviewed this conflict in an …

Epibeat figure

Transgenerational Epigenetic Inheritance: Why should you care?

Transgenerational epigenetic inheritance (TEI) is a relatively recent concept that has a major role in biological processes. Although we are just starting to understand the role of TEI in human health, the implications seem enormous. Our recent article in Clinical Epigenetics summarizes evidence in animal models showing transgenerational phenotypes that …


Increased risk of insulin resistance in rat offsprings exposed prenatally to white rice

Mustapha Umar Imam1, Maznah Ismail1,2 1 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; emails: mustyimam@gmail.com,  maznahis@upm.edu.my; fax +603-8947-2116. 2 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia   Dietary factors and habits are …


Imprinting, epigenetic markers and assisted reproductive technologies (ARTs)

Epigenetics refers to changes in gene regulation that are do not related to changes in the primary sequence of DNA. It can be reversible and heritable throughout cell division, and its regulation is characterized by several modifications, such as DNA methylation and post-translational changes in the histone proteins. In addition, …

stem cell differentiation, DNA methylation

iPSC Epigenetic Memory: One more Roadblock for Regenerative Medicine?

The discovery of induced pluripotent stem cells (iPSCs) and the creation of clinically relevant cell types derived from them, have been great leaps toward the implementation of stem cell based therapies and disease models. But in recent years, concerns have risen about iPSCs “remembering” their original cell types and favoring …

Epigenetic Effects of Folic Acid on Development

Maternal Diet Affects DNA Methylation Patterns in Offspring

There is now mounting evidence that diet and other environmental factors can have widespread and long-lasting influences on a developing fetus. Historically, folic acid supplementation is recommended to pregnant mothers as a means to prevent developmental disorders and birth defects. However, there is still no clear understanding how such supplementation …


Dad’s Deficient Diet Harms His Offspring: Epigenetics To Blame?

Doctors have long known that a pregnant woman needs adequate levels of folate (also known as vitamin B9) to help prevent serious birth defects. New research in mice now suggests that a father’s level of folate prior to conception also plays a critical role in the baby’s health, through a …