Histones in Paternal Epigenetic Inheritance

A Role for Histones in Paternal Epigenetic Inheritance

A group of children grew up in the same neighborhoods of Quebec in the late 1960’s, but only some of them would reach their fifth birthday. In one of the first studies of its kind, Fabia and Thuy combed through hospital records to ask what made these children different from …

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Chaperoning Histone Inheritance

Chaperoning Histone Inheritance

One of the great mysteries of epigenetics is how histones, the eponymous beads on a DNA string, are divided onto newly synthesized DNA strands during cell division. Histones carry modifications that serve as important signals in determining gene expression, regulating developmental programs, and their alteration can even mark disease states …

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Sperm transfer aged epigenome to offspring

Advanced Paternal Age at Conception Increases Risk of Age-Related Diseases in Offspring

As a person ages, they become more prone to diseases, including cancer and neurodegeneration. Having children when you are older can also affect the health of your offspring, increasing the risk for neuropsychiatric disorders, among many others [1], [2]. Sperm contribute epigenetic information to the zygote [3] that can affect …

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Epigenetic inheritance exercise

Offspring Reap the Benefits of Parent’s Exercise

The epigenetic landscapes are vulnerable to many environmental insults, including unhealthy diet, famine, psychological stress and disease. Mounting evidence is indicating physical exercise can reprogram the epigenome and the epigenetic reprogramming of transcription is crucial for health and performance adaptations. Interestingly, environmental epigenetic reprogramming does not appear to be limited …

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Ancestral alcohol consumption may influence your drinking behavior and responses to stress

Ancestral alcohol consumption may influence your drinking behavior and responses to stress

Gregg E. Homanics, PhD Gregory Rompala University of Pittsburgh It has long been assumed that the father’s lifestyle choices prior to conception bared little consequence for the health of his children since DNA is largely unchanged over the lifespan. However, many controlled studies in genetically identical rodents have shown that …

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Gene Imprinting

Genomic imprinting – new insight into the methylation patterns of humans

Genomic imprinting is an epigenetic gene-marking phenomenon that is mostly established in germline and results in monoallelic gene expression according to parental origin.1 The process of genomic imprinting is associated with prenatal development providing functions necessary for normal fetal growth. In addition to prenatal expression, postnatal gene imprinting may also …

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Listen Up Dads! Paternal Weight and Obesity Influences Sperm Epigenetics

The obesity epidemic is a widely discussed, but controversial topic. Although diet and exercise are the best way to combat weight gain, some people seem to gain weight easier than others and have a more difficult time getting rid of it. The role of maternal and prenatal nutrition is concretely …

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Early-Life Epigenetic Programming by Endocrine Disrupting Chemicals

     The ‘developmental origins of adult health and disease’ (DOHaD) hypothesis postulates that adverse influences early in development can program the risks for adverse health outcomes in adult life. In modern societies, exposure to man-made environmental contaminants is a potential risk factor for developmental programming of chronic disease. Endocrine-disrupting …

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