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Chromatin Density Matters

Histone methylation mediated by polycomb repressive complex 2 (PRC2) is involved in numerous biological processes, including cell differentiation, proliferation, and stem cell plasticity. Enhancer of Zeste homolog 2 (Ezh2), a subunit of PRC2, is a histone methyltransferase that specifically methylates histone H3 on lysine 27 (H3K27) and regulates polycomb gene …

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Discovery of the first chemical inhibitor of histone demethylation

The study of post-translational modification of histone tails represents one of the largest areas of research in the field of epigenetics.  An improved understanding of how these modifications are added, recognized, and removed is essential to understand the mechanisms underlying epigenetic-based human diseases and to allow for the discovery of …

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DNA methylation & histone modification

Analyzing two epigenetic marks (DNA methylation and histone modification) by one sequencing run

Epigenetic regulation is a complicated network involving DNA methylation, histone modification and non-coding RNAs, which all play in concert to control the epigenetic machinery. The cross talk between DNA methylation and histone modification is one of the most important interactions in establishing the epigenetic signature and was traditionally studied using …

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The kidneys are responsible for salt reabsorption in the body

Epigenetic and dietary regulation of salt-sensitive hypertension

Hypertension (also known as high blood pressure) is a disease that is often heritable and can be a direct consequence of dietary factors.  A high intake of dietary salt is one factor that can potentially affect the expression of genes involved in regulating blood pressure, and thus contributes to the …

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Prediction of polyadenylation site usage from epigenetic modifications

In this computational study, the authors explore several links between epigenetic factors (including DNA methylation, nucleosomal association, and histone modifications) and the usage of polyadenylation (poly(A)) sites in transcribed messages.

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