Hello World
shutterstock_101520898

The Role of Epigenetics in Cognitive Ageing

Dr. Karen Mather, Genetics & Genomics Group Leader at the Centre for Healthy Brain Ageing (CHeBA), UNSW Australia As we age, there is a decline in cognitive performance but there is great variability in the rate and degree of cognitive ageing observed across older adults.  The domains of information processing …

READ MORE →
Oxidative Stress and Epigenetics: a Novel Link Established Through Histone Adduction

Oxidative Stress and Epigenetics: a Novel Link Established Through Histone Adduction

Damage to cellular macromolecules caused by reactive oxygen species (ROS) produced during oxidative stress contributes to the pathogenesis of many disease states. One target of ROS is the 1,4-diene structure of polyunsaturated fatty acids (PUFAs), which is highly susceptible to peroxidation. An important outcome of lipid peroxidation is the generation …

READ MORE →
shutterstock_139219241-300x239

Gene Transcription: Not Always Dictated by Histone Modifications!

The proper regulation of gene expression is of fundamental importance in the maintenance of normal growth and development.  Misregulation of genes can lead to such outcomes as cancer, diabetes and neurodegenerative disease.  A key step in gene regulation occurs during the transcription of the chromosomal DNA into messenger RNA by …

READ MORE →
This one goes with the war theme!

The Battle for HOXC10 in the War Against Breast Cancer

Tamoxifen and aromatase inhibitors (AIs) are both treatment options for patients with breast tumors that express estrogen receptor (ER) α and that require estrogen for growth. Tamoxifen competes with estrogen in binding to the ER, but does not activate the receptor. In comparison, AIs lower estrogen levels in the body …

READ MORE →
shutterstock_175048175

NEW LINK FOUND BETWEEN BREAST CANCER AND EPIGENETICS

Breast cancer is one of the most common cancers worldwide in females. Researchers from the University of California, Los Angeles (UCLA) found that PIAS1 is linked to breast tumorigenesis. PIAS1 is a transcriptional repressor that has SUMO (small ubiquitin-like modifier) E3 ligase activity. Recently, it had been explored that PIAS1 …

READ MORE →
aacr_image

AACR Special Conference on Chromatin and Epigenetics in Cancer

The advancements in Next-Generation sequencing technology have recently helped researchers uncover the importance of epigenetic modifying enzymes in many human cancers.  Numerous different cancer cells contain mutations in genes that encode histone-modifying enzymes and chromatin-remodeling factors, leading scientists and doctors to conclude that misregulated epigenetic processes are of central importance …

READ MORE →
shutterstock_97971080

Put down that water bottle! BPA Exposure Alters Epigenetic Profile in Neurons

Bisphenol A (BPA) is an industrial chemical that is present in many consumer products, including plastic bottles and other food and beverage containers.  Although BPA has been used routinely since the 1960s, exposure to BPA has recently gained a lot of attention due to its proposed effect on brain development. …

READ MORE →
shutterstock_117418438

You can take a gene out of context, but can you take context out of a gene?

A gene’s precise chromatin context profoundly affects its regulation. For example, genes located near nucleosomes containing acetylated histones are generally actively transcribed. By contrast, genes located near nucleosomes containing histones methylated at specific lysine residues are usually transcriptionally repressed. But is the opposite also true? Do specific gene sequences affect …

READ MORE →