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HDAC Inhibitor Stops HPV in its Tracks

HDAC Inhibitor Stops HPV in its Tracks

It may come as a surprise for a virus to be name-dropped during a stand-up comedy show, but in Ali Wong’s Netflix special “Baby Cobra” she exclaims, “Everybody has HPV, OK? Everybody has it… If you don’t have it yet, you go and get it.”

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Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Balancing Bones: Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Walking the dog is not typically considered a dangerous task, but when an unexpected tug on the leash leads to a fall and a broken hip, it certainly becomes one. As we age, the balance between the formation of new bone and the removal of old bone shifts. New bone …

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Histones in Paternal Epigenetic Inheritance

A Role for Histones in Paternal Epigenetic Inheritance

A group of children grew up in the same neighborhoods of Quebec in the late 1960’s, but only some of them would reach their fifth birthday. In one of the first studies of its kind, Fabia and Thuy combed through hospital records to ask what made these children different from …

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Aging Promotes Tissue Regeneration and Less Scar Formation

Aging Promotes Tissue Regeneration and Less Scar Formation

If Harry Potter had been older during his confrontation with Voldemort, he may not have even gotten his famous scar. Dermatologists have long noted that skin wounds in elderly patients tend to heal with less scarring than those in younger patients [1]. Recent work from Nishiguchi et al shows that …

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Acetylation in Alzheimer's disease

Dysregulation of Histone Acetylation in Alzheimer’s Disease

In Alzheimer’s disease (AD) pathology, neuronal histone acetylation is reduced at memory-related genes [1]. Nativio et al specifically researched H4K16ac, a regulator of chromatin compaction, because it plays an important role in cellular aging and senescence [2]. By comparing the genome-wide profiles of H4K16ac in brain tissues from AD patients …

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Aerobic Exercise Increases Function of the Hippocampus, HAT and HDAC Activity

Staying physically active is an effective method of delaying age-related cognitive decline [1]. Aerobic exercise increases expression of brain derived neurotrophic factor (BDNF) in the hippocampus, maintaining cognitive function [2], [3]. This exercise induced BDNF expression is accompanied by increased acetylation of histone 3 [4]. It is unknown what molecular …

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HDAC Inhibitors as a Treatment for Acute Myocardial Infarction

HDAC Inhibitors as a Treatment for Acute Myocardial Infarction

Histone deacytylase (HDAC) inhibitors are gaining interest in the treatment of cardiovascular diseases for their ability to decrease the damage to heart tissue after an ischemic event [1]. Cardiovascular diseases increase HDAC activity, altering histone acetylation [6, 7]. HDAC inhibitors can be used to decrease these epigenetic changes caused by …

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Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

          In Mathias Malzieu’s novel “The Boy with the Cuckoo-Clock Heart”, Jack is born with a frozen, dysfunctional heart which, fortunately for him, is soon replaced with a workable heart made from a cuckoo clock. If found in a similar situation, who would not desire such an amazing, albeit strange, miracle? …

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