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Low HDAC3 Expression Leads to Endometriosis-Linked Infertility

Low HDAC3 Expression Leads to Endometriosis-Linked Infertility

From fostering the development of new life to literally pushing out a 6 to 10-pound baby, the uterus is a pretty phenomenal organ. Every month it thickens its endometrial cells, the cells that line the inner wall of the uterus, in preparation for implantation of an embryo. But, if implantation …

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How Foreign DNA is Hushed

Cellular Antivirus: How Foreign DNA is Hushed

Like a computer antivirus, our cells are constantly on the lookout for things that do not belong. Our body’s first line of defense, immune cells, circulate through the bloodstream and attack anything they perceive as different, but what happens when something foreign manages to avoid the immune system long enough …

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HDAC Inhibitor Stops HPV in its Tracks

HDAC Inhibitor Stops HPV in its Tracks

It may come as a surprise for a virus to be name-dropped during a stand-up comedy show, but in Ali Wong’s Netflix special “Baby Cobra” she exclaims, “Everybody has HPV, OK? Everybody has it… If you don’t have it yet, you go and get it.”

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Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Balancing Bones: Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Walking the dog is not typically considered a dangerous task, but when an unexpected tug on the leash leads to a fall and a broken hip, it certainly becomes one. As we age, the balance between the formation of new bone and the removal of old bone shifts. New bone …

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Histones in Paternal Epigenetic Inheritance

A Role for Histones in Paternal Epigenetic Inheritance

A group of children grew up in the same neighborhoods of Quebec in the late 1960’s, but only some of them would reach their fifth birthday. In one of the first studies of its kind, Fabia and Thuy combed through hospital records to ask what made these children different from …

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Aging Promotes Tissue Regeneration and Less Scar Formation

Aging Promotes Tissue Regeneration and Less Scar Formation

If Harry Potter had been older during his confrontation with Voldemort, he may not have even gotten his famous scar. Dermatologists have long noted that skin wounds in elderly patients tend to heal with less scarring than those in younger patients [1]. Recent work from Nishiguchi et al shows that …

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Acetylation in Alzheimer's disease

Dysregulation of Histone Acetylation in Alzheimer’s Disease

In Alzheimer’s disease (AD) pathology, neuronal histone acetylation is reduced at memory-related genes [1]. Nativio et al specifically researched H4K16ac, a regulator of chromatin compaction, because it plays an important role in cellular aging and senescence [2]. By comparing the genome-wide profiles of H4K16ac in brain tissues from AD patients …

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Aerobic Exercise Increases Function of the Hippocampus, HAT and HDAC Activity

Staying physically active is an effective method of delaying age-related cognitive decline [1]. Aerobic exercise increases expression of brain derived neurotrophic factor (BDNF) in the hippocampus, maintaining cognitive function [2], [3]. This exercise induced BDNF expression is accompanied by increased acetylation of histone 3 [4]. It is unknown what molecular …

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