An incursion into the epigenetic landscape of our ancestors

An incursion into the epigenetic landscape of our ancestors

Studying the evolution of epigenetic regulation in humans has proved to be quite difficult due to the lack of ancient material. Together in collaboration, stem cell biologist, Eran Meshorer and computational biologist, Liran Carmel were able to circumvent this problem by analyzing the genomes of two archaic humans, a Neanderthal …

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stem cell differentiation, DNA methylation

iPSC Epigenetic Memory: One more Roadblock for Regenerative Medicine?

The discovery of induced pluripotent stem cells (iPSCs) and the creation of clinically relevant cell types derived from them, have been great leaps toward the implementation of stem cell based therapies and disease models. But in recent years, concerns have risen about iPSCs “remembering” their original cell types and favoring …

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RNA methylation, stem cell differentiation, and RNA stability

RNA Methylation: The Next Big Thing in Stem Cell Differentiation and RNA Stability

While DNA methylation is probably the longest studied and best understood epigenetic modification, methylation of RNA is gaining increased appreciation, especially recently.  N6-methyladenosine (m6A) in RNA has been observed to be the most frequently occurring epigenetic modification in mRNAs in eukaryotic organisms, but the function of this modification is still …

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Epigenetics, DNA hydroxymethylation, and liver cancer

Somatic Cells Turned Pluripotent by Acid Treatment – Major Breakthrough, Or Too Good To Be True?

The potential use of induced pluripotent stem cells in medicine has the power to completely revolutionize the way physicians treat human diseases.  Imagine the possibility of treating diseased or damaged tissue by taking a patient’s own cells from an unaffected tissue, and turning them into healthy cells to replace the …

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Dad’s Deficient Diet Harms His Offspring: Epigenetics To Blame?

Doctors have long known that a pregnant woman needs adequate levels of folate (also known as vitamin B9) to help prevent serious birth defects. New research in mice now suggests that a father’s level of folate prior to conception also plays a critical role in the baby’s health, through a …

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DNA Methylation Age Clock

Wanna Be Forever 21? It May Be Possible By Resetting Your DNA Methylation Age Clock

As an organism ages, cells and tissues differentiate and change. These changes can include accumulation of DNA mutations, alterations to telomeres, decay of cellular and tissue structures, and changes in gene expression. Both differentiation of tissues and age effects are at least partially caused by epigenetic modifications of the genome, …

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DNA hydroxymethylation and neuron development

DNA Hydroxymethylation and Neuron Development

It has been well known for many years that DNA methylation plays many roles in gene regulation and can direct different cell pathways such as apoptosis, differentiation, cancer, and aging. Although DNA methylation can be extremely stable – able to persist through multiple generations – it can also be quite …

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Epigenetics, DNA methylation, and chicken growth

Chicken Little Can Blame It On Her Epigenetics!

While most of us will be hopping on the scale and hoping for a relatively low weight this holiday season, poultry farmers will be weighing their birds hoping for just the opposite. Chickens are the most commonly eaten poultry in the world and those bred for consumption are categorized as …

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