Frog Eyes Might Be Key to Retinal Regeneration

Frog Eyes Might Be the Key to Retinal Regeneration

Often said to be the windows to the soul, our eyes are one of the main ways we perceive the world around us. Vision loss, whether due to aging or injury, can be devastating and often hinders the ability to work, leading to economic stress [1]. Current treatments for vision …

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C. elegans Histone Methyltransferase Targets Regions to Silence

How a C. elegans Histone Methyltransferase Targets Regions to Silence

As an organism grows and develops, its cells are rapidly dividing and committing to different fates. Some, for example, will become immune cells, while others will become skin cells. What decides the different fates of these cells is how their genes are expressed. For example, to become a skin cell, …

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Epigenetic Link to Recurrent Miscarriage

An Epigenetic Link to Recurrent Miscarriage

Miscarriage, or natural loss of a pregnancy, is a common reproductive problem and can be upsetting for families trying to have a child. Recurrent miscarriage (RM) – two or more miscarriages – often occur because of problems that arise very early in embryonic development. A common cause of RM is …

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Losing Heterochromatin to Determine Cell Fate

Losing Heterochromatin to Determine Cell Fate

In the moments after fertilization, the tiny mass that is the embryo sets in motion developmental programs that will transform it into a human being. One of the earliest steps in human development is the formation of the germ layers. Humans and other animals in the Chordata phylum, have three …

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Transient Imprinting of Genes in the Human Placenta

Transient Imprinting of Genes in the Human Placenta

When the fertilization occurs, the maternal and paternal pronuclei have thousands of opposite methylated regions. Most of this germline methylation are resolved during the postfertilization epigenetic reprogramming by active mechanism for the sperm-derived methylated regions and depending on DNA replication for the oocyte-derived ones. There is a subset of regions …

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DNA methylation in the placenta

DNA Methylation in the Placenta: accelerated aging in pregnancy complications

The placenta is a unique organ as it is an extra-embryonic tissue primarily regulated by the fetal genome and shared between mother and fetus. However, it is a transient organ that is only needed throughout pregnancy and gestation and then is discarded after delivery. The essential role of the placenta …

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5-Formlycytosine (5fC): A new base?

5-Formlycytosine (5fC): A new base?

DNA methylation and hydroxymethylation are well-established key players in gene regulation. Although many would agree that 5hmC also plays a critical role, there is still some debate over whether it serves a functional role, or is merely an artifact of DNA de-methylation. Even still, other intermediates of de-methylation are actively …

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Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential

Epigenetics of Early Pregnancy Loss: Hypomethylation and Genetic Instability May Contribute to Decreased Implantation Potential of Monosomy Blastocysts

Blair R. McCallie1,3, Jason C. Parks1,3, Alyssa L. Patton1, Darren K. Griffin3, William B. Schoolcraft2, Mandy G. Katz-Jaffe1,2 1 National Foundation for Fertility Research, Lone Tree, Colorado, 80124, United States of America, 2 Colorado Center for Reproductive Medicine, Lone Tree, Colorado, 80124, United States of America, 3 School of Biosciences, …

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