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Frog Eyes Might Be Key to Retinal Regeneration

Frog Eyes Might Be the Key to Retinal Regeneration

Often said to be the windows to the soul, our eyes are one of the main ways we perceive the world around us. Vision loss, whether due to aging or injury, can be devastating and often hinders the ability to work, leading to economic stress [1]. Current treatments for vision …

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Altering Heterochromatin Disguises Malaria from Host

Hidden in Plain Sight: How Altering Heterochromatin Disguises Malaria from its Host

Like a criminal adopting a disguise to evade detection, malaria parasites inside red blood cells express specific proteins on the blood cell surface to hide from the immune system. When the malaria parasites, Plasmodium falciparum, are eventually detected, they simply switch the identity of the surface protein in a process …

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Epigenetic Link to Recurrent Miscarriage

An Epigenetic Link to Recurrent Miscarriage

Miscarriage, or natural loss of a pregnancy, is a common reproductive problem and can be upsetting for families trying to have a child. Recurrent miscarriage (RM) – two or more miscarriages – often occur because of problems that arise very early in embryonic development. A common cause of RM is …

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Losing Heterochromatin to Determine Cell Fate

Losing Heterochromatin to Determine Cell Fate

In the moments after fertilization, the tiny mass that is the embryo sets in motion developmental programs that will transform it into a human being. One of the earliest steps in human development is the formation of the germ layers. Humans and other animals in the Chordata phylum, have three …

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A Flash-Frozen View of Condensing Chromatin

A Flash-Frozen View of Condensing Chromatin

For cells to divide, they must first condense their DNA into the X-shape familiar from introductory biology textbooks. While the process of cell division has been studied for over 100 years, how exactly our DNA condenses in three-dimensions within the nucleus remains a mystery. To better understand this condensation process, …

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Mapping the Chromatin Landscape of Cancers

Mapping the Chromatin Landscape of Cancers

A betrayal of our own cells against us, cancer is a devastating disease that affects over 18 million people world-wide [1]. With more than 200 different types of cancer, most with diverse modes of action and variable outcomes among people, a deeper understanding of how different cancers function and progress …

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Aging Promotes Tissue Regeneration and Less Scar Formation

Aging Promotes Tissue Regeneration and Less Scar Formation

If Harry Potter had been older during his confrontation with Voldemort, he may not have even gotten his famous scar. Dermatologists have long noted that skin wounds in elderly patients tend to heal with less scarring than those in younger patients [1]. Recent work from Nishiguchi et al shows that …

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Chaperoning Histone Inheritance

Chaperoning Histone Inheritance

One of the great mysteries of epigenetics is how histones, the eponymous beads on a DNA string, are divided onto newly synthesized DNA strands during cell division. Histones carry modifications that serve as important signals in determining gene expression, regulating developmental programs, and their alteration can even mark disease states …

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