DNA Methylation & Lifespan
Aging, Environment, & DiseaseArticle SummariesDNA Methylation and Hydroxymethylation

DNA Methylation Rate May Determine Lifespan in Mammals

Species within the class Mammalia have a wide range of lifespans, from mice with a lifespan of 2 years to humans with a lifespan of over 100 years. Several non-molecular theories have been proposed to explain these lifespan variations, including body mass and metabolic rate [1]. Alternatively, research on ageing-associated …

HDAC Inhibitors as a Treatment for Acute Myocardial Infarction
Aging, Environment, & DiseaseArticle SummariesHistone Modifications

HDAC Inhibitors as a Treatment for Acute Myocardial Infarction

Histone deacytylase (HDAC) inhibitors are gaining interest in the treatment of cardiovascular diseases for their ability to decrease the damage to heart tissue after an ischemic event [1]. Cardiovascular diseases increase HDAC activity, altering histone acetylation [6, 7]. HDAC inhibitors can be used to decrease these epigenetic changes caused by …

Article SummariesTopic Reviews

Can epigenetics decode a cell’s history? Linking somatic DNA methylation, DNA repair, and gene expression

Mammalian Genomic DNA (mainly cytosines, in the doublet CpG) can be covalently modified by methylation, which is layered on the primary genetic information and alters gene expression. There are two patterns of DNA methylation. The first is stable methylation, called imprinting. Imprinting is inherited in a sex-specific fashion and is …

Epigenetics of exercise
Article SummariesDNA Methylation and Hydroxymethylation

Exercise: No Pain, No Gain (in DNA Methylation)

Through twin studies and the use of laboratory mice, it is becoming increasingly clear that epigenetic patterns are heavily influenced by the environment. These influences can be either harmful or beneficial to our health. For example, long-term smokers often exhibit characteristic changes in the DNA methylation patterns of key genes …