Mitochondrial epigenetics neurodegeneration

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

Epigenetic inheritance exercise

Offspring Reap the Benefits of Parent’s Exercise

The epigenetic landscapes are vulnerable to many environmental insults, including unhealthy diet, famine, psychological stress and disease. Mounting evidence is indicating physical exercise can reprogram the epigenome and the epigenetic reprogramming of transcription is crucial for health and performance adaptations. Interestingly, environmental epigenetic reprogramming does not appear to be limited …

Epigenetics and Obesity

Epigenetic Marks Associated to Severe Obesity

There is growing evidence that DNA methylation might contribute to obesity. Candidate gene methylation studies in animal models and humans have demonstrated methylation changes in promoters of various genes that are implicated in obesity, appetite control and/or metabolism, insulin signaling, immunity, growth and circadian clock regulation. Severe obesity in children …

CHL1 hypermethylation

CHL1 Hypermethylation in Breast Cancer

Breast cancer (BC) is the most common cancer among women and one of the leading causes of cancer-related deaths worldwide (1-3). It is a clinically heterogeneous disease, with at least 5 different subtypes (4) and quite variable prognosis, even within a subtype. In spite of early detection programmes, unfortunately 20-30% …

Fibrosis radiation therapy epigenetics

Epigenetic Predisposition to Radiation Fibrosis

Radiotherapy is a highly efficient treatment for many cancers including breast cancer. Intraoperative radiotherapy (IORT), a relatively new type of radiation therapy, has proven successful as a curative treatment for early cancer stages. However, in spite of great improvements in dose delivery and imaging technology, unwanted exposure of healthy tissue …

Alzheimer’s & the Brain Stem

Epigenetic Dysregulation Within the Brainstem in Alzheimer’s Disease

The elusive nature of the early stages of Alzheimer’s disease (AD) impedes scientific breakthroughs in diagnostics or efficient therapeutics for this devastating disorder. To date, the long-prevailing theories of genetic contribution do not adequately explain the pathogenesis of the disease and, alternatively, epigenetic regulation has been proposed as a key …

epigenetic mechanisms in allergic diseases

Asthma & Histone Acetylation: an important epigenetic mechanism in allergic diseases

Epigenetic regulation is thought to be one of the most important mechanisms contributing to the development and clinical course of chronic immunological diseases like allergies and asthma. DNA methylation has been extensively studied in this context, which has not been a case of histone modifications such as histone acetylation or …

ncRNA is Synergistically Regulated by Various Epi-Modifications

Non-coding RNA Expression is Synergistically modulated by Various Types of Epigenetic Modifications

It is well known that most of the mammalian genome is transcribed, producing large amounts of non-coding RNAs (ncRNAs). The two main types of ncRNA are micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs). MiRNAs are a recently discovered and well-characterized class of ncRNAs that are frequently dysregulated in different …