Sperm transfer aged epigenome to offspring

Advanced Paternal Age at Conception Increases Risk of Age-Related Diseases in Offspring

As a person ages, they become more prone to diseases, including cancer and neurodegeneration. Having children when you are older can also affect the health of your offspring, increasing the risk for neuropsychiatric disorders, among many others [1], [2]. Sperm contribute epigenetic information to the zygote [3] that can affect …

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DNA Methylation & Lifespan

DNA Methylation Rate May Determine Lifespan in Mammals

Species within the class Mammalia have a wide range of lifespans, from mice with a lifespan of 2 years to humans with a lifespan of over 100 years. Several non-molecular theories have been proposed to explain these lifespan variations, including body mass and metabolic rate [1]. Alternatively, research on ageing-associated …

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Aerobic Exercise Increases Function of the Hippocampus, HAT and HDAC Activity

Staying physically active is an effective method of delaying age-related cognitive decline [1]. Aerobic exercise increases expression of brain derived neurotrophic factor (BDNF) in the hippocampus, maintaining cognitive function [2], [3]. This exercise induced BDNF expression is accompanied by increased acetylation of histone 3 [4]. It is unknown what molecular …

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HDAC Inhibitors as a Treatment for Acute Myocardial Infarction

HDAC Inhibitors as a Treatment for Acute Myocardial Infarction

Histone deacytylase (HDAC) inhibitors are gaining interest in the treatment of cardiovascular diseases for their ability to decrease the damage to heart tissue after an ischemic event [1]. Cardiovascular diseases increase HDAC activity, altering histone acetylation [6, 7]. HDAC inhibitors can be used to decrease these epigenetic changes caused by …

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Colorectal cancer and obesity

Risk for Colorectal Cancer is Increased by Obesity-related Gene Expression Changes

Colorectal cancer is an age-related disease traditionally seen in populations over the age of 50. In recent years, colorectal cancer has become more prevalent in younger individuals, and obesity is thought to be a major risk factor. However, the molecular mechanisms underlying this increased risk remains unclear. Since DNA methylation …

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Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

          In Mathias Malzieu’s novel “The Boy with the Cuckoo-Clock Heart”, Jack is born with a frozen, dysfunctional heart which, fortunately for him, is soon replaced with a workable heart made from a cuckoo clock. If found in a similar situation, who would not desire such an amazing, albeit strange, miracle? …

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Sex Influences Brain Aging by Impacting DNA Methylation

Sex Influences Brain Aging by Impacting DNA Methylation

While sex differences across aging and in the incidence of neurodegenerative diseases are well documented, relatively little data is available that compares sex-specific epigentic changes in the aging brain.1  Recent studies have identified specific loci with age-realted hyper- or hypo- methylation changes in liver, lung, and heart – but no …

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DNA methylation is as active mark of aging and age-related cognitive impairment in the medial prefrontal cortex

DNA Methylation is as Active Mark of Aging and Cognitive Impairment

Aging and age-related cognitive decline have been reported to be associated to transcriptomic alterations related to neural activity, synaptic plasticity and inflammation in specific brain regions, including the hippocampus and the medial prefrontal cortex (mPFC).1-4  Furthermore, previous epigenetic studies indicate that DNA methylation in the hippocampus is linked to cognitive …

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