Mapping the Chromatin Landscape of Cancers

Mapping the Chromatin Landscape of Cancers

A betrayal of our own cells against us, cancer is a devastating disease that affects over 18 million people world-wide [1]. With more than 200 different types of cancer, most with diverse modes of action and variable outcomes among people, a deeper understanding of how different cancers function and progress …

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Aging Promotes Tissue Regeneration and Less Scar Formation

Aging Promotes Tissue Regeneration and Less Scar Formation

If Harry Potter had been older during his confrontation with Voldemort, he may not have even gotten his famous scar. Dermatologists have long noted that skin wounds in elderly patients tend to heal with less scarring than those in younger patients [1]. Recent work from Nishiguchi et al shows that …

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Gene Expression Regulation in ALS

Gene Expression Dysregulation in Familial Amyotrophic Lateral Sclerosis

Researchers have identified a new molecular player involved in the pathology of the neurodegenerative disease Amyotrophic Lateral Sclerosis (ALS), and it’s all thanks to the humble fruit fly. A recent study by Mallik et al in the Journal of Cell Biology took advantage of the tractable genetics of the model …

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Potential Treatment for Rett Syndrome Through Maintenance of X-inactivation

Maintenance of X-inactivation: A Step Towards a Potential Treatment for Rett Syndrome

Not only do the brown and black splotches of fur on calico cats make them pretty cute, they also reflect a moment early in mammalian development called X-chromosome inactivation. While females have two X-chromosomes, males only have one, so to ensure that the expression of genes on the X-chromosome is …

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Acetylation in Alzheimer's disease

Dysregulation of Histone Acetylation in Alzheimer’s Disease

In Alzheimer’s disease (AD) pathology, neuronal histone acetylation is reduced at memory-related genes [1]. Nativio et al specifically researched H4K16ac, a regulator of chromatin compaction, because it plays an important role in cellular aging and senescence [2]. By comparing the genome-wide profiles of H4K16ac in brain tissues from AD patients …

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Seafood toxins alter DNA methylation

Sex-specific Alterations in DNA Methylation from Prenatal Exposure to Seafood Toxins

Exposure to toxins in the womb can alter DNA methylation in the offspring [1], [2], persisting after birth [3]. Changes in DNA methylation in umbilical cord white blood cells (UCWBCs) have been linked to increased prevalence of disease, such as asthma [4]. To date, studies have dealt with a single …

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Hypomethylation in cancer and aging

Different DNA Hypomethylation Patterns in Cancer and Aging

The risk of developing cancer increases with age [1]. The mechanisms that increase the prevalence of cancer with age are not fully understood. Several studies have found the presence of polycomb-target gene promoter hypermethylation in aging and cancer [2], [3]. Perez et al researched whether aging and cancer share changes …

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Inflammation and Cognitive Decline

Age-related Dysregulation of Cytokine CXCL10 is Linked to Cognitive Decline

Chronic inflammation is a hallmark of aging pathology [1], [2]. Chronic inflammation is a risk factor for decreased cognitive performance [3], [4] and dementia [5] in older populations. Bradborn et al analyzed 35 cytokines in humans from the MyoAge study [6] to determine which are important for cognitive decline and …

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