5mc to 5hmc

Potential of 5-hmC and TET Expression as Cancer Biomarkers

The role of epigenetics in cancer and developmental biology has become the focus of extensive research. 5-hydoxymethylcytosine (5-hmC) is an epigenetic modification that arises from the oxidation of 5-methylcytosine (5-mC) by the epigenetic regulatory proteins belonging to the TET (ten-eleven translocation) family of α-ketoglutarate-dependent deoxygenases.  The TET enzymes are responsible …