Low HDAC3 Expression Leads to Endometriosis-Linked Infertility

Low HDAC3 Expression Leads to Endometriosis-Linked Infertility

From fostering the development of new life to literally pushing out a 6 to 10-pound baby, the uterus is a pretty phenomenal organ. Every month it thickens its endometrial cells, the cells that line the inner wall of the uterus, in preparation for implantation of an embryo. But, if implantation …

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Tau on the Epigenome of Alzheimer’s Brains

Untangling the Role of Tau on the Epigenome of Alzheimer’s Brains

Forgetting where you put your car keys or the address of your aunt’s house is pretty normal, but for people with Alzheimer’s disease, this kind of forgetfulness and memory loss is just the tip of the iceberg. As the neurons in the brains of these patients degenerate, their memory loss …

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How Foreign DNA is Hushed

Cellular Antivirus: How Foreign DNA is Hushed

Like a computer antivirus, our cells are constantly on the lookout for things that do not belong. Our body’s first line of defense, immune cells, circulate through the bloodstream and attack anything they perceive as different, but what happens when something foreign manages to avoid the immune system long enough …

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Implicating Methylation Variability in Depression

Implicating Methylation Variability in Depression

When Scott Kelly touched back down to Earth after nearly a year in space, scientists found that he was no longer strictly identical to his twin brother Mark [1]. While Scott’s DNA sequence was no different from his brother’s, he did have a number of epigenetic changes compared to Mark. …

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HDAC Inhibitor Stops HPV in its Tracks

HDAC Inhibitor Stops HPV in its Tracks

It may come as a surprise for a virus to be name-dropped during a stand-up comedy show, but in Ali Wong’s Netflix special “Baby Cobra” she exclaims, “Everybody has HPV, OK? Everybody has it… If you don’t have it yet, you go and get it.”

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Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Balancing Bones: Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Walking the dog is not typically considered a dangerous task, but when an unexpected tug on the leash leads to a fall and a broken hip, it certainly becomes one. As we age, the balance between the formation of new bone and the removal of old bone shifts. New bone …

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Mapping the Chromatin Landscape of Cancers

Mapping the Chromatin Landscape of Cancers

A betrayal of our own cells against us, cancer is a devastating disease that affects over 18 million people world-wide [1]. With more than 200 different types of cancer, most with diverse modes of action and variable outcomes among people, a deeper understanding of how different cancers function and progress …

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Aging Promotes Tissue Regeneration and Less Scar Formation

Aging Promotes Tissue Regeneration and Less Scar Formation

If Harry Potter had been older during his confrontation with Voldemort, he may not have even gotten his famous scar. Dermatologists have long noted that skin wounds in elderly patients tend to heal with less scarring than those in younger patients [1]. Recent work from Nishiguchi et al shows that …

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