Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Battle of the Sexes: Autosomal DNA methylation tells us that men and women are more different than we thought

The genetic factors that give rise to the obvious morphological differences between males and females have long been known. Recently however, some less obvious disparities have emerged at the molecular level in the form of sex specific metabolic profiles, where any attempts to attribute these differences to genomic variations in …

Regulatory RNA

Enhancer RNAs as molecular traps

Results from ENCODE released in 2007 suggested that 80% of the human genome plays a role in at least one RNA biochemical and/or chromatin modelling event; much higher than previously understood. More importantly, a significant portion of this active genome is transcribed into RNA, without any known corresponding functional protein. …