Implicating Methylation Variability in Depression
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Implicating Methylation Variability in Depression

When Scott Kelly touched back down to Earth after nearly a year in space, scientists found that he was no longer strictly identical to his twin brother Mark [1]. While Scott’s DNA sequence was no different from his brother’s, he did have a number of epigenetic changes compared to Mark. …

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A Flash-Frozen View of Condensing Chromatin
Chromatin Structure

A Flash-Frozen View of Condensing Chromatin

For cells to divide, they must first condense their DNA into the X-shape familiar from introductory biology textbooks. While the process of cell division has been studied for over 100 years, how exactly our DNA condenses in three-dimensions within the nucleus remains a mystery. To better understand this condensation process, …

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HDAC Inhibitor Stops HPV in its Tracks
Aging, Environment, & DiseaseHistone Modifications

HDAC Inhibitor Stops HPV in its Tracks

It may come as a surprise for a virus to be name-dropped during a stand-up comedy show, but in Ali Wong’s Netflix special “Baby Cobra” she exclaims, “Everybody has HPV, OK? Everybody has it… If you don’t have it yet, you go and get it.”

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Epigenetic Regulators Are Important for Maintaining Bone Homeostasis
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone Modifications

Balancing Bones: Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Walking the dog is not typically considered a dangerous task, but when an unexpected tug on the leash leads to a fall and a broken hip, it certainly becomes one. As we age, the balance between the formation of new bone and the removal of old bone shifts. New bone …

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Mapping the Chromatin Landscape of Cancers
Aging, Environment, & DiseaseChromatin StructureTools & Technology

Mapping the Chromatin Landscape of Cancers

A betrayal of our own cells against us, cancer is a devastating disease that affects over 18 million people world-wide [1]. With more than 200 different types of cancer, most with diverse modes of action and variable outcomes among people, a deeper understanding of how different cancers function and progress …

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Histones in Paternal Epigenetic Inheritance
Histone ModificationsImprinting and Inheritance

A Role for Histones in Paternal Epigenetic Inheritance

A group of children grew up in the same neighborhoods of Quebec in the late 1960’s, but only some of them would reach their fifth birthday. In one of the first studies of its kind, Fabia and Thuy combed through hospital records to ask what made these children different from …

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Simultaneous Gene Expression and Chromatin Landscape in Single Cells
Tools & Technology

A Simultaneous Picture of Gene Expression and Chromatin Landscape in Single Cells

As we move through the day, it’s easy to forget that individual cells, organized into tissues and tissues into organs, act in harmony to give us life. Over the years, scientists have developed new techniques to investigate how gene expression, chromatin state, and methylation determines developmental behavior, at the level …

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Aging Promotes Tissue Regeneration and Less Scar Formation
Aging, Environment, & DiseaseChromatin StructureHistone Modifications

Aging Promotes Tissue Regeneration and Less Scar Formation

If Harry Potter had been older during his confrontation with Voldemort, he may not have even gotten his famous scar. Dermatologists have long noted that skin wounds in elderly patients tend to heal with less scarring than those in younger patients [1]. Recent work from Nishiguchi et al shows that …

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