Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Intragenic methylation: searching for biomarker needles in the epigenetic haystack

Natalie S Shenker and James Flanagan The Epigenetics Unit, Dept. of Surgery and Cancer, Imperial College London, London, UK Gene expression is thought to be correlated with, if not regulated by, DNA methylation at the promoter. Dogma states that a methylated promoter inhibits transcription, while unmethylated promoters can be accessed …