Autism Awareness Month
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

April is Autism Awareness Month: Increased levels of 5-hmC may influence gene regulation in Autism Spectrum Disorder

The prevalence of Autism Spectrum Disorder (ASD) has increased by roughly 30% since 2012. The CDC recently reported that one in 68 children in the United States is affected by ASD, compared to one in 88 just two years ago. This enhanced occurrence could be attributed to advancements in the …

Epigenetics of Hamster Reproduction
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Fall is in the Air: DNA Methylation Regulates Seasonal Hormonal Changes in Hamsters.

Ah the fall…the leaves are changing color, you can feel a chill in the air, the days are getting shorter, and your libido is decreasing…wait, what?!?  Well, maybe not in humans, but seasonal changes that affect the length of day, or photoperiod, can have a profound effect on reproductive behavior …

DNA Methylation and HydroxymethylationTools & Technology

Cut It Out! Characterization of PvuRts1I Homologues and Hydroxymethylated DNA Digestion

Restriction enzymes are critical tools that have aided researchers in making scientific breakthroughs for decades.  The discovery and characterization of the 5-methylcytosine (5-mC) DNA modification also resulted in the unearthing of 5-mC-sensitive or -dependent restriction enzymes, however these enzymes are generally not capable of distinguishing 5-mC from 5-hydroxymethylcytosine (5-hmC).   Although …

Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

All Grown Up: 5-hmC Changes in Human Fetus and Adult Cerebellum

The role of DNA methylation in healthy embryonic and postnatal neurological development has been well established in recent years.  In addition to 5-methylcytosine (5-mC), high levels of 5-hydroxymethylcystosine (5-hmC) have also been detected in brain and other neurological tissue.  Several studies have shown that defects in the ten-eleven translocation (TET) …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Epigenetic Regulation is Involved in Host Antiviral Defense Mechanisms

Influenza is the virus that causes the flu, and can result in serious, sometimes fatal infections.  Influenza virus is easily transmitted within a population raising concerns of it causing an epidemic, or worse, a pandemic.  In recent years, the highly pathogenic H5N1 and H1N1 viruses have caused thousands of deaths …