Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone Modifications

The Epigenetics of Stroke

Stroke is the 4th leading cause of death in the United States, taking 130,000 lives each year as well as incurring $36.5 billion combined costs of medical expenses and lost productivity. Advanced age is a risk factor for stroke. 66% of patients hospitalized due to stroke are over 65 years …

Chromatin StructureDevelopmental Biology & Stem Cells

3D Chromatin Organization, Transcription, and Behavior

The chromosomes of differentiated cells contain heterochromatic and euchromatic compartments. Heterochromatin is highly condensed and associated with repressed transcription, whereas in euchromatin  transcription is generally active. Spatial organization of heterochromatin can vary vastly among different differentiated cell types1. In contrast to differentiated cells, embryonic stem cells contain only sparse heterochromatic …

The Mysterious Role of non-CpG Methylation in the Brain
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

The Mysterious Role of non-CpG Methylation in the Brain

DNA methylation is a key mechanism of epigenetic regulation of gene expression and contributes to a multitude of process such as embryonic development, cancer, aging and learning and memory. In the metazoan genome, CpG methylation is the primary form of DNA methylation and is therefore extensively studied. However, key questions …

Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Seasons influence the methylation profiles of newborns: more evidence that mom’s diet during pregnancy has lasting effects in her offspring.

Metastable epialleles (ME) are gene alleles that are differentially expressed through epigenetic regulatory mechanisms. The DNA methylation status of an ME is established during embryonic development, and can be maintained later into life. The differential methylation of these MEs contribute to phenotypic diversity between individuals and provides an explanation for …