Epigenetics and Allergies
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

New Year, New Hay Fever Season, and New Role for Epigenetics in Allergies

Itching of the eyes and nose, nasal congestion, sneezing, and runny nose are some symptoms of Allergic Rhinitis, better known as hay fever or seasonal allergies, which affects ~30% of people worldwide. In a recent PLOS Genetics publication, scientists from Sweden and the US investigated genome-wide DNA methylation and gene …

5-hmC apple
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

An Apple a Day Keeps the DNA Methylation Away! Vitamin C and DNA Demethylation in Mouse ES Cells

DNA methylation is an epigenetic modification that is essential for normal development and also plays important roles in diverse cellular functions, such as genomic imprinting, X-chromosome inactivation, suppression of repetitive DNA elements, carcinogenesis, and other human diseases. In the last few years, scientists have focused on better understanding the process …

Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Starting from Scratch: DNA Methylation Marks Erased Through 5-hmC in Primordial Germ Cells

A growing body of evidence indicates that ancestral environmental factors can influence the physiology and behavior of the offspring, a process known as epigenetic inheritance. However, in each generation the epigenetically inherited modifications are thought to be erased in cells called primordial germ cells (PGCs), the precursors to sperm and …

Cognitive decline in the brain
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Don’t forget about Dnmt’s

There is not a lot of knowledge about the enzymes that influence the molecular pathways underlying the normal aging process. A recent publication in Nature Neuroscience showed that the DNA methyltransferase Dnmt3a2 is critically involved in age-associated cognitive decline in mice. Oliveira et al.  found that up regulating Dnmt3a2 can …