DNA Methylation is as Active Mark of Aging and Cognitive Impairment
Aging and age-related cognitive decline have been reported to be associated to transcriptomic alterations related to neural activity, synaptic plasticity and inflammation in specific brain regions, including the hippocampus and the medial prefrontal cortex (mPFC).1-4 Furthermore, previous epigenetic studies indicate that DNA methylation in the hippocampus is linked to cognitive …
Estrogen, Memory, & Aging: DNA methylation of the ERα promoter contributes to transcriptional differences in age across the hippocampus
Lara Ianov1,2, Ashok Kumar1, Thomas C. Foster1,2 1Department of Neuroscience, McKnight Brain Institute, 2Genetics and Genomics Program, Genetics Institute, University of Florida, Gainesville, FL 32611 Estradiol (E2) influences a number of processes that are important for maintaining healthy brain function, including memory. The ability of E2 to protect the brain …