Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc
Aging, Environment, & DiseaseHistone Modifications

Activated protein C ameliorates diabetic nephropathy (kidney disease) by epigenetically inhibiting the enzyme p66Shc

Activated protein C (aPC) is a serine protease that is lost during diabetes. Previously it has been shown that aPC protects against diabetic nephropathy (dNP)1, a progressive kidney disease caused by damage to the capillaries.  aPC’s cytoprotective effect in diabetic nephropathy may be related to its in vitro ability to …

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