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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

The Epigenetics of Immunodeficiency

An increasing number of genetically complex diseases have been demonstrated to also have epigenetic determinants. Epigenetic alterations can be the result of various factors, including external influences and the activity of susceptibility gene variant products. Despite the recognition of non-genetic determinants in the pathogenesis of primary immunodeficiencies, to date little …