Mitochondrial epigenetics neurodegeneration
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

READ MORE →
5-Formlycytosine (5fC): A new base?
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

5-Formlycytosine (5fC): A new base?

DNA methylation and hydroxymethylation are well-established key players in gene regulation. Although many would agree that 5hmC also plays a critical role, there is still some debate over whether it serves a functional role, or is merely an artifact of DNA de-methylation. Even still, other intermediates of de-methylation are actively …

READ MORE →
DNA methylation as age prediction marker
DNA Methylation and HydroxymethylationTools & Technology

Whodunit? Using DNA Methylation in Forensics

For some reason crime scene investigations and murder mysteries seem to fascinate us. So much so, that the countless books and television shows never seem to get old. Like most things on television however, life in a forensics lab is often portrayed to be much more fantastical than real life …

READ MORE →
shutterstock_309107990
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance

Listen Up Dads! Paternal Weight and Obesity Influences Sperm Epigenetics

The obesity epidemic is a widely discussed, but controversial topic. Although diet and exercise are the best way to combat weight gain, some people seem to gain weight easier than others and have a more difficult time getting rid of it. The role of maternal and prenatal nutrition is concretely …

READ MORE →
shutterstock_127766126
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Epigenetic Mechanisms Underlying Fetal Alcohol Spectrum Disorders

Alcohol consumption during any stage of pregnancy has been shown to result in a range of congenital and cognitive defects, collectively known as fetal alcohol spectrum disorder (FASD). Alcohol (EtOH) consumed by the mother is readily able to cross the placenta where it remains trapped in the amniotic fluid resulting …

READ MORE →
shutterstock_178610135
Chromatin StructureDevelopmental Biology & Stem Cells

Of Mice and Men: The Evolution of Cis-Regulatory Elements

DNase Hypersenestive sites (DHSs) are regions within the genome that are susceptible to cleavage by the enzyme DNase I. These regions are susceptible because they lie in uncondensed regions of euchromatin and are readily accessible to the DNase enzyme. In vivo however, these regions are also accessible to regulatory proteins …

READ MORE →
Zinc_finger_rendered
Aging, Environment, & DiseaseHistone ModificationsTools & Technology

Artificial Transcription Factors – A new class of epigenetic drug

Aberrant epigenetic status resulting in dysregulation of gene expression is a hallmark of many cancers and other diseases. In the last decade, countless time and energy has been spent in efforts to develop drugs targeting DNA methylation and histone modifications. To date however, none of these epigenetic drugs are sequence …

READ MORE →
The Impact of Environment on Epigenetics and Metal Health
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

The Impact of Environment on Mental Health – the Epigenetics of Bulimia

Bulimia Nervosa, a well-known eating disorder is commonly characterized by recurrent binge-eating, subsequent compensatory behaviors, and body image obsession. In addition to these common symptoms, some individuals with BN also suffer from other disorders such as mood fluctuations, anxiety, substance abuse, and personality problems. However, other individuals do not. Due …

READ MORE →