Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance

Early-Life Epigenetic Programming by Endocrine Disrupting Chemicals

     The ‘developmental origins of adult health and disease’ (DOHaD) hypothesis postulates that adverse influences early in development can program the risks for adverse health outcomes in adult life. In modern societies, exposure to man-made environmental contaminants is a potential risk factor for developmental programming of chronic disease. Endocrine-disrupting …

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Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsUncategorized

Early-life Exposure to Substance Abuse and the Risk for Type 2 Diabetes

Type 2 diabetes (T2D) is a chronic non-communicable disease that generally develops after the age of 40 and therefore believed to be associated with aging. There is, however,increasing experimental and epidemiological evidence that risk of T2D and obesity which is an important risk factor for T2D may be epigenetically programmed during critical windows …