Erasing Breast Cancer
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Erasing Breast Cancer: miRNAs and Epigenetic Factors Play Key Roles in Aggressive Breast Cancer Mechanisms

Cancer research is perhaps the poster child for the importance of integrating epigenetic analyses into a disease model. As research in the epigenetics of cancer continues to grow, relationships between myriad epigenetic regulators can become quite clear. In a recent study by Pier Paolo Pandolfi and colleagues, epigenetic players including …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Down the Drain? 1MNA Acts as a Potent ‘Methylation Sink’ in Cancer Cells

The cancer field consistently proves to be one of the most critical areas for investigations into mechanisms governing tight epigenetic regulation, as nearly all types of cancers demonstrate misregulated epigenetic patterns. Most studies focus on the final epigenomic landscape in terms of histone and DNA modifications and methylomes; relatively few, …

Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Lost in translation? New findings suggest a critical role for cytosine methylation in tRNAs

While cytosine methylation in the DNA context will continue to be an important marker for epigenetic discoveries, current trends in the cytosine methylation game indicate diverse and critical roles of the modification in the RNA context. Much attention has been paid recently to findings in mRNA methylation, suggesting an important …

Chromatin StructureDNA Methylation and HydroxymethylationHistone ModificationsTools & Technology

Prediction of polyadenylation site usage from epigenetic modifications

In this computational study, the authors explore several links between epigenetic factors (including DNA methylation, nucleosomal association, and histone modifications) and the usage of polyadenylation (poly(A)) sites in transcribed messages.