CHL1 hypermethylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

CHL1 Hypermethylation in Breast Cancer

Breast cancer (BC) is the most common cancer among women and one of the leading causes of cancer-related deaths worldwide (1-3). It is a clinically heterogeneous disease, with at least 5 different subtypes (4) and quite variable prognosis, even within a subtype. In spite of early detection programmes, unfortunately 20-30% …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

DNA methylome profiling beyond promoters: taking an epigenetic snapshot of the breast tumor microenvironment

Aside from tumorigenic cells, which have been the primary research target in the past decades, breast and other tumors contain various other cell populations (immune cells, fibroblasts, adipocytes, endothelial cells), which are referred to as the tumor microenvironment (TME). The TME is an active component of breast cancer disease and …

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