CHL1 hypermethylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

CHL1 Hypermethylation in Breast Cancer

Breast cancer (BC) is the most common cancer among women and one of the leading causes of cancer-related deaths worldwide (1-3). It is a clinically heterogeneous disease, with at least 5 different subtypes (4) and quite variable prognosis, even within a subtype. In spite of early detection programmes, unfortunately 20-30% …

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Fibrosis radiation therapy epigenetics
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Epigenetic Predisposition to Radiation Fibrosis

Radiotherapy is a highly efficient treatment for many cancers including breast cancer. Intraoperative radiotherapy (IORT), a relatively new type of radiation therapy, has proven successful as a curative treatment for early cancer stages. However, in spite of great improvements in dose delivery and imaging technology, unwanted exposure of healthy tissue …

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ncRNA is Synergistically Regulated by Various Epi-Modifications
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNATools & Technology

Non-coding RNA Expression is Synergistically modulated by Various Types of Epigenetic Modifications

It is well known that most of the mammalian genome is transcribed, producing large amounts of non-coding RNAs (ncRNAs). The two main types of ncRNA are micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs). MiRNAs are a recently discovered and well-characterized class of ncRNAs that are frequently dysregulated in different …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Identification of 21 DNA Hypermethylated Hotspots Associated with Breast Cancer Metastasis

Breast cancer is one of the most common diseases in women and almost an eighth of the women population is suffering from breast cancer. Currently, there are several methods to diagnose and treat breast cancer, including genetic screening. In 2013, Angelina Jolie announced that she carried the BRCA1 mutation and …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Intragenic methylation: searching for biomarker needles in the epigenetic haystack

Natalie S Shenker and James Flanagan The Epigenetics Unit, Dept. of Surgery and Cancer, Imperial College London, London, UK Gene expression is thought to be correlated with, if not regulated by, DNA methylation at the promoter. Dogma states that a methylated promoter inhibits transcription, while unmethylated promoters can be accessed …

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Aging, Environment, & DiseaseRegulatory RNA

Genome-Wide DNA Methylome Analysis Reveals Epigenetically Dysregulated Non-coding RNAs in Human Breast Cancer

Yongsheng Li, Yunpeng Zhang, Shengli Li, Jianping Lu, Juan Chen, Yuan Wang, Yixue Li, Juan Xu, Xia Li The development of human cancer is mediated by both genetic and epigenetic alterations of the cell. Since the discovery of altered DNA methylation in human cancer, DNA methylation studies of cancer have …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

DNA methylome profiling beyond promoters: taking an epigenetic snapshot of the breast tumor microenvironment

Aside from tumorigenic cells, which have been the primary research target in the past decades, breast and other tumors contain various other cell populations (immune cells, fibroblasts, adipocytes, endothelial cells), which are referred to as the tumor microenvironment (TME). The TME is an active component of breast cancer disease and …

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