Ancestral alcohol consumption may influence your drinking behavior and responses to stress

Ancestral alcohol consumption may influence your drinking behavior and responses to stress

Gregg E. Homanics, PhD Gregory Rompala University of Pittsburgh It has long been assumed that the father’s lifestyle choices prior to conception bared little consequence for the health of his children since DNA is largely unchanged over the lifespan. However, many controlled studies in genetically identical rodents have shown that …

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Gene Imprinting

Genomic imprinting – new insight into the methylation patterns of humans

Genomic imprinting is an epigenetic gene-marking phenomenon that is mostly established in germline and results in monoallelic gene expression according to parental origin.1 The process of genomic imprinting is associated with prenatal development providing functions necessary for normal fetal growth. In addition to prenatal expression, postnatal gene imprinting may also …

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Listen Up Dads! Paternal Weight and Obesity Influences Sperm Epigenetics

The obesity epidemic is a widely discussed, but controversial topic. Although diet and exercise are the best way to combat weight gain, some people seem to gain weight easier than others and have a more difficult time getting rid of it. The role of maternal and prenatal nutrition is concretely …

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Early-Life Epigenetic Programming by Endocrine Disrupting Chemicals

     The ‘developmental origins of adult health and disease’ (DOHaD) hypothesis postulates that adverse influences early in development can program the risks for adverse health outcomes in adult life. In modern societies, exposure to man-made environmental contaminants is a potential risk factor for developmental programming of chronic disease. Endocrine-disrupting …

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DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity.

De Novo DNA Cytosine Methyltransferase Enzyme Dynamics

The DNA methyltransferases (DNMT) are one busy enzyme family! While they are responsible for establishing and maintaining the mammalian cytosine methylome, they aren’t one and the same, as they take on some diverse roles. The DNMTs can from complexes with more than one DNMT to accomplish additional functions and their …

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Figure 1: Factors involved in impaired male infertility due to reproductive aging.

Paternal Age and Epigenetics

Maternal aging has been shown to cause infertility, pregnancy complications, spontaneous abortion, congenital anomalies, and perinatal complications. However, the impact of paternal ageing on semen quality and reproductive function has still been controversial. To address this, Drs. Sharma, Professor Agarwal and their co-authors have extensively reviewed this conflict in an …

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Transgenerational Epigenetic Inheritance: Why should you care?

Transgenerational epigenetic inheritance (TEI) is a relatively recent concept that has a major role in biological processes. Although we are just starting to understand the role of TEI in human health, the implications seem enormous. Our recent article in Clinical Epigenetics summarizes evidence in animal models showing transgenerational phenotypes that …

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Increased risk of insulin resistance in rat offsprings exposed prenatally to white rice

Mustapha Umar Imam1, Maznah Ismail1,2 1 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; emails: mustyimam@gmail.com,  maznahis@upm.edu.my; fax +603-8947-2116. 2 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia   Dietary factors and habits are …

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