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Prediction of polyadenylation site usage from epigenetic modifications

In this computational study, the authors explore several links between epigenetic factors (including DNA methylation, nucleosomal association, and histone modifications) and the usage of polyadenylation (poly(A)) sites in transcribed messages.

5mc to 5hmc

Potential of 5-hmC and TET Expression as Cancer Biomarkers

The role of epigenetics in cancer and developmental biology has become the focus of extensive research. 5-hydoxymethylcytosine (5-hmC) is an epigenetic modification that arises from the oxidation of 5-methylcytosine (5-mC) by the epigenetic regulatory proteins belonging to the TET (ten-eleven translocation) family of α-ketoglutarate-dependent deoxygenases.  The TET enzymes are responsible …