Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

Can Epigenetics Fix a Broken Heart? Epigenetic Modifications Enhance the Cardiac Competency of Adult Stem Cells

          In Mathias Malzieu’s novel “The Boy with the Cuckoo-Clock Heart”, Jack is born with a frozen, dysfunctional heart which, fortunately for him, is soon replaced with a workable heart made from a cuckoo clock. If found in a similar situation, who would not desire such an amazing, albeit strange, miracle? …

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Sex Influences Brain Aging by Impacting DNA Methylation

Sex Influences Brain Aging by Impacting DNA Methylation

While sex differences across aging and in the incidence of neurodegenerative diseases are well documented, relatively little data is available that compares sex-specific epigentic changes in the aging brain.1  Recent studies have identified specific loci with age-realted hyper- or hypo- methylation changes in liver, lung, and heart – but no …

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DNA methylation is as active mark of aging and age-related cognitive impairment in the medial prefrontal cortex

DNA Methylation is as Active Mark of Aging and Cognitive Impairment

Aging and age-related cognitive decline have been reported to be associated to transcriptomic alterations related to neural activity, synaptic plasticity and inflammation in specific brain regions, including the hippocampus and the medial prefrontal cortex (mPFC).1-4  Furthermore, previous epigenetic studies indicate that DNA methylation in the hippocampus is linked to cognitive …

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Mitochondrial epigenetics neurodegeneration

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

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Epigenetic inheritance exercise

Offspring Reap the Benefits of Parent’s Exercise

The epigenetic landscapes are vulnerable to many environmental insults, including unhealthy diet, famine, psychological stress and disease. Mounting evidence is indicating physical exercise can reprogram the epigenome and the epigenetic reprogramming of transcription is crucial for health and performance adaptations. Interestingly, environmental epigenetic reprogramming does not appear to be limited …

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Epigenetics and Obesity

Epigenetic Marks Associated to Severe Obesity

There is growing evidence that DNA methylation might contribute to obesity. Candidate gene methylation studies in animal models and humans have demonstrated methylation changes in promoters of various genes that are implicated in obesity, appetite control and/or metabolism, insulin signaling, immunity, growth and circadian clock regulation. Severe obesity in children …

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CHL1 hypermethylation

CHL1 Hypermethylation in Breast Cancer

Breast cancer (BC) is the most common cancer among women and one of the leading causes of cancer-related deaths worldwide (1-3). It is a clinically heterogeneous disease, with at least 5 different subtypes (4) and quite variable prognosis, even within a subtype. In spite of early detection programmes, unfortunately 20-30% …

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Fibrosis radiation therapy epigenetics

Epigenetic Predisposition to Radiation Fibrosis

Radiotherapy is a highly efficient treatment for many cancers including breast cancer. Intraoperative radiotherapy (IORT), a relatively new type of radiation therapy, has proven successful as a curative treatment for early cancer stages. However, in spite of great improvements in dose delivery and imaging technology, unwanted exposure of healthy tissue …

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